{"id":"W4393308525","doi":"10.1073/pnas.2316303121","title":"Femtosecond pulsed laser photodynamic therapy activates melanin and eradicates malignant melanoma","year":2024,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Photodynamic Therapy Research Studies","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital; Princess Margaret Cancer Centre; University of British Columbia; University Health Network","funders":"Cancer Prevention and Research Institute of Texas; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Canadian Institutes of Health Research; Universidade de São Paulo; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; University of Toronto; Ciência sem Fronteiras; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Photodynamic therapy; Photosensitizer; Melanin; Melanoma; In vivo; Cancer research; Medicine; Chemistry; Photochemistry; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007616825,0.000145153,0.0001322804,0.0001348786,0.00008256098,0.0001353236,0.00007670736,0.0002015613,0.001078869],"category_scores_gemma":[0.00006674287,0.00007060398,0.00008170876,0.00008314897,0.000115606,0.0001337576,0.0001398547,0.000271264,0.0001410335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000159346,"about_ca_system_score_gemma":0.0001198726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003043253,"about_ca_topic_score_gemma":0.0005472633,"domain_scores_codex":[0.9999616,0.000007089148,0.000002221435,0.000008637441,0.0000122854,0.000008168061],"domain_scores_gemma":[0.9999801,0.00000479146,0.000004935794,0.000003147301,0.000002190279,0.000004903099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001469614,0.000008033909,0.000061777,0.00001089437,8.822593e-7,0.00001181806,0.000005679102,0.00003909026,0.9987238,0.0000404063,0.00001446111,0.001068594],"study_design_scores_gemma":[0.000007629961,0.0003890998,0.00225389,0.00000485297,0.000004462042,0.0002451203,0.00002145605,0.0007649658,0.9937411,0.00006963439,0.002495939,0.000001789679],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942411,0.001796026,0.002483221,0.00006841058,0.00001617867,0.00001884196,0.00002618291,0.00004840117,0.001301621],"genre_scores_gemma":[0.9941562,0.00128081,0.002003268,0.00003503792,0.000007618167,0.00001484962,0.00004107532,0.0000103945,0.002450708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001078869,"threshold_uncertainty_score":0.00360918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03476205093294787,"score_gpt":0.3333022764131433,"score_spread":0.2985402254801954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}