{"id":"W4393308525","doi":"10.1073/pnas.2316303121","title":"Femtosecond pulsed laser photodynamic therapy activates melanin and eradicates malignant melanoma","year":2024,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Photodynamic Therapy Research Studies","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital; Princess Margaret Cancer Centre; University of British Columbia; University Health Network","funders":"Cancer Prevention and Research Institute of Texas; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Canadian Institutes of Health Research; Universidade de São Paulo; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; University of Toronto; Ciência sem Fronteiras; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Photodynamic therapy; Photosensitizer; Melanin; Melanoma; In vivo; Cancer research; Medicine; Chemistry; Photochemistry; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001068269,0.000131441,0.0002414555,0.0002704065,0.0001600866,0.00004412256,0.0003506111,0.00007079589,0.0000578505],"category_scores_gemma":[0.0002337896,0.00007263103,0.0000820481,0.0006886999,0.001200339,0.0003037668,0.0001086153,0.0002367264,0.000001535366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005058089,"about_ca_system_score_gemma":0.00006582904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001224784,"about_ca_topic_score_gemma":1.388429e-7,"domain_scores_codex":[0.99825,0.00000801501,0.0002608792,0.0003130488,0.0009616104,0.0002064304],"domain_scores_gemma":[0.9994058,0.0002577566,0.0001265282,0.00001008318,0.0001452536,0.00005456006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008849455,0.00004294221,0.002247807,0.0001461644,0.0001302873,8.299003e-8,0.0003655949,0.00000157318,0.9913713,0.00361754,0.0004258203,0.001562392],"study_design_scores_gemma":[0.0003988372,0.0002005961,0.06945414,0.0003123905,0.00001620182,0.0000475272,0.0002530408,0.001723613,0.9079303,0.0189589,0.0006186821,0.00008582358],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856956,0.00275369,1.08321e-7,0.008057771,0.00001769338,0.0003578475,0.00002915683,0.00002737225,0.003060771],"genre_scores_gemma":[0.9976581,0.001267774,0.0001472352,0.0002984971,0.00004696958,0.00002804374,3.260934e-7,0.000008975851,0.0005441254],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08344106,"threshold_uncertainty_score":0.4422699,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03476205093294787,"score_gpt":0.3333022764131433,"score_spread":0.2985402254801954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}