{"id":"W4393314591","doi":"10.1007/s10620-024-08310-2","title":"Deletion of Mixed Lineage Kinase Domain Like Pseudokinase Aggravates Chronic Alcohol-Induced Liver Injury via Increasing Apoptosis","year":2024,"lang":"en","type":"article","venue":"Digestive Diseases and Sciences","topic":"Alcohol Consumption and Health Effects","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Korean Association for the Study of the Liver; Ministry of Science and ICT, South Korea","keywords":"Steatosis; Necroptosis; Apoptosis; Biology; Internal medicine; Inflammation; TUNEL assay; Fatty liver; Endocrinology; Alcoholic liver disease; Transcriptome; Programmed cell death; Andrology; Immunology; Cirrhosis; Biochemistry; Gene expression; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000210385,0.0005050662,0.0003698113,0.0003109669,0.0002263191,0.0002651486,0.0002690156,0.0003955648,0.003694692],"category_scores_gemma":[0.000127526,0.0002235536,0.0004447347,0.0002138319,0.000415943,0.0003489576,0.0002029759,0.0009486706,0.0005440362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002791385,"about_ca_system_score_gemma":0.0004230523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005728687,"about_ca_topic_score_gemma":0.0007670201,"domain_scores_codex":[0.9998104,0.00003563587,0.00002146927,0.00002765264,0.00003120815,0.00007366361],"domain_scores_gemma":[0.9998755,0.00001461119,0.00003756906,0.00001260538,0.000007762616,0.00005191576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002227762,0.0002344696,0.0004613089,0.0001105421,0.00002467507,0.0001419662,0.00003250775,0.0001528466,0.9940593,0.0004596196,0.0001328974,0.001962031],"study_design_scores_gemma":[0.0003164432,0.001738742,0.00577466,0.00001498924,0.00008349441,0.0006855071,0.0001468068,0.002659194,0.9837738,0.0002303796,0.004557697,0.00001836215],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950256,0.0009515461,0.00225714,0.0002251665,0.00009686573,0.00003539947,0.0004609585,0.00008390188,0.0008634524],"genre_scores_gemma":[0.9951309,0.0005515672,0.001266303,0.00006255952,0.0000156416,0.00004899997,0.000422325,0.00001307391,0.0024886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003694692,"threshold_uncertainty_score":0.01235998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04839506393189521,"score_gpt":0.3531252904599105,"score_spread":0.3047302265280153,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}