{"id":"W4393314855","doi":"10.20944/preprints202403.1581.v1","title":"Safety, Tolerability and EEG-Based Target Engagement of STP1 (PDE3,4 Inhibitor and NKCC1 Antagonist), in a Randomized Clinical Trial in a Subgroup of Patients with ASD","year":2024,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Tolerability; Antagonist; Randomized controlled trial; Electroencephalography; Psychology; Internal medicine; Medicine; Psychiatry; Adverse effect; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001470829,0.001092178,0.002134443,0.0003100874,0.0003204638,0.0006717264,0.0004649599,0.001237696,0.003373081],"category_scores_gemma":[0.001736433,0.0004286985,0.001369579,0.00027322,0.0006878958,0.0007830338,0.0002956373,0.001694131,0.0003961951],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004535413,"about_ca_system_score_gemma":0.0009543429,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003747892,"about_ca_topic_score_gemma":0.001446464,"domain_scores_codex":[0.9993678,0.0003381133,0.0000618318,0.0001078642,0.00004749439,0.00007695525],"domain_scores_gemma":[0.9993054,0.0002079036,0.0001943412,0.00005667491,0.00005432144,0.0001813903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9531707,0.007641015,0.001264593,0.0006554478,0.001074153,0.00008501517,0.00007717434,0.0003263933,0.01067674,0.0001031179,0.0004379945,0.02448775],"study_design_scores_gemma":[0.7650642,0.2256103,0.005458554,0.00003467353,0.0009012625,0.00008941699,0.00004955341,0.000588995,0.001133369,0.000165145,0.000881155,0.00002327011],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932711,0.002795924,0.0004883696,0.0003484091,0.0001821859,0.001788236,0.0003978672,0.00003568665,0.0006922146],"genre_scores_gemma":[0.9921688,0.001785257,0.001115124,0.0004759385,0.0002277334,0.002861605,0.0005278806,0.00001196815,0.0008256427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003373081,"threshold_uncertainty_score":0.01128411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09945830642673004,"score_gpt":0.3905480520971117,"score_spread":0.2910897456703817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}