{"id":"W4393318831","doi":"10.1038/s41523-024-00629-3","title":"Automated mitotic spindle hotspot counts are highly associated with clinical outcomes in systemically untreated early-stage triple-negative breast cancer","year":2024,"lang":"en","type":"article","venue":"npj Breast Cancer","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institutes of Health; George M. Eisenberg Foundation for Charities; Breast Cancer Research Foundation","keywords":"Medicine; Triple-negative breast cancer; Oncology; Internal medicine; Cohort; Breast cancer; Stage (stratigraphy); Cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001618624,0.0004441144,0.0006364062,0.000108768,0.0000822351,0.00007264904,0.0002125339,0.0003234979,0.0002319262],"category_scores_gemma":[0.00004326855,0.0003346757,0.0001761178,0.00043454,0.0002093734,0.00001963926,0.00008498206,0.0002714782,0.00006304203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005149171,"about_ca_system_score_gemma":0.0004775085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004383964,"about_ca_topic_score_gemma":0.004636265,"domain_scores_codex":[0.9977133,0.0001589361,0.0004873209,0.0007929374,0.0003242504,0.0005233028],"domain_scores_gemma":[0.9989774,0.00008013737,0.0002031479,0.0003329095,0.0002620171,0.0001443796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006631391,0.0002733685,0.9909696,0.0001139964,0.001943998,0.0001242069,0.0001017387,0.00009647723,0.0003194168,0.00001573244,0.003953232,0.001425089],"study_design_scores_gemma":[0.002422697,0.00007797058,0.9946759,0.001066992,0.0002322839,0.00004342706,0.00006879769,0.0003012653,0.0002213548,0.000004525237,0.0004705475,0.0004141908],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894746,0.001898352,0.000008283526,0.00159469,0.001005297,0.0005352051,0.004690466,0.0003157906,0.0004772924],"genre_scores_gemma":[0.996171,0.0004039722,0.0000229757,0.0002724352,0.0003207796,0.000325318,0.000113451,0.00008719887,0.002282847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006696399,"threshold_uncertainty_score":0.9999105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.014489536226999,"score_gpt":0.3081748325583574,"score_spread":0.2936852963313584,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}