{"id":"W4393321517","doi":"10.1016/j.bea.2024.100120","title":"Immobilization of novel synthesized phosphobetaine zwitterions on polyethersulphone (PES) hemodialysis membranes to induce hemocompatibility: Experimental, molecular docking, and ex-vivo inflammatory biomarker investigations","year":2024,"lang":"en","type":"article","venue":"Biomedical Engineering Advances","topic":"Polymer Surface Interaction Studies","field":"Materials Science","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Saskatchewan Health Research Foundation","keywords":"Membrane; Zwitterion; Chemistry; Fibrinogen; Ex vivo; Docking (animal); Pharmacology; Combinatorial chemistry; Biochemistry; Organic chemistry; Medicine; In vitro; Molecule","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002987811,0.0002417332,0.0003505964,0.0003370473,0.0000709315,0.00006729098,0.0001562495,0.00007248843,0.0001324063],"category_scores_gemma":[0.000377142,0.0002129038,0.00007018478,0.0006147174,0.0002441572,0.0002752518,0.0001067192,0.00009136584,0.00001588895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008140563,"about_ca_system_score_gemma":0.00004759415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005604349,"about_ca_topic_score_gemma":0.000002675615,"domain_scores_codex":[0.998377,0.0000390797,0.0004675045,0.0004601891,0.0004115597,0.0002446368],"domain_scores_gemma":[0.9990175,0.0004050419,0.00007893243,0.0002563542,0.00004658227,0.0001955546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002812722,0.0001056452,0.00002231086,0.0001875834,0.00005568829,0.000006109427,0.0007106973,0.004234411,0.9928868,0.000124849,0.00003015674,0.001607628],"study_design_scores_gemma":[0.0002520433,0.00006038064,0.0001799329,0.0004018978,0.00003118967,0.00000706879,0.0002729711,0.01342114,0.9792989,0.000011781,0.005847343,0.0002153018],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9800652,0.006229431,0.01186929,0.0005815301,0.000692662,0.0002445505,0.00005453063,0.0002351042,0.00002768061],"genre_scores_gemma":[0.9947222,0.00006697895,0.004932065,0.00008696454,0.00004178689,0.00009569184,0.000006384587,0.0000310605,0.00001682876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01465702,"threshold_uncertainty_score":0.8681963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01612265419960297,"score_gpt":0.2807095238947246,"score_spread":0.2645868696951217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}