{"id":"W4393356522","doi":"10.3390/ijms25073866","title":"The Heterogeneity of Post-Menopausal Disease Risk: Could the Basis for Why Only Subsets of Females Are Affected Be Due to a Reversible Epigenetic Modification System Associated with Puberty, Menstrual Cycles, Pregnancy and Lactation, and, Ultimately, Menopause?","year":2024,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Birth, Development, and Health","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Bone and Joint Health Institute; University of Calgary","funders":"","keywords":"Context (archaeology); Menopause; Offspring; Disease; Fertility; Pregnancy; Biology; Physiology; Medicine; Demography; Environmental health; Population; Endocrinology; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001421006,0.000184644,0.0006824924,0.0004947103,0.0004408436,0.001151521,0.0008388921,0.001041337,0.003159464],"category_scores_gemma":[0.002876797,0.0001288366,0.0003975671,0.0004291485,0.001373015,0.001263484,0.0006145004,0.001038218,0.0005808098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004232175,"about_ca_system_score_gemma":0.0007723781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002493239,"about_ca_topic_score_gemma":0.002799558,"domain_scores_codex":[0.9993494,0.0001094808,0.00004385346,0.0002819519,0.00009803088,0.0001172204],"domain_scores_gemma":[0.9987566,0.0004416681,0.000324419,0.0001155991,0.0002271145,0.0001344751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.001018175,0.0002216236,0.4877961,0.002719263,0.0008327363,0.004251303,0.006561378,0.0005535487,0.03838591,0.05980861,0.03353105,0.3643202],"study_design_scores_gemma":[0.00006116161,0.0004125143,0.7699943,0.001012547,0.0004778808,0.008423971,0.005800891,0.0009879804,0.003624034,0.07392441,0.1351367,0.0001436679],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4575265,0.3564942,0.01426969,0.1381557,0.003081571,0.0001152106,0.003928628,0.0001692439,0.02625917],"genre_scores_gemma":[0.8844665,0.08818066,0.002469869,0.01507226,0.003466068,0.00008812929,0.001157249,0.00005121877,0.005048121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003159464,"threshold_uncertainty_score":0.01056945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03106549332903355,"score_gpt":0.3181888961149438,"score_spread":0.2871234027859103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}