{"id":"W4393364883","doi":"10.1016/j.jad.2024.03.165","title":"Spectral signatures of psilocybin, lysergic acid diethylamide (LSD) and ketamine in healthy volunteers and persons with major depressive disorder and treatment-resistant depression: A systematic review","year":2024,"lang":"en","type":"review","venue":"Journal of Affective Disorders","topic":"Psychedelics and Drug Studies","field":"Psychology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; University of Toronto; Brain and Cognition Discovery Foundation; University Health Network","funders":"National Institute on Drug Abuse; National Institute of Mental Health; National Institute on Aging; Canadian Institutes of Health Research","keywords":"Psilocybin; Psychology; Ketamine; Serotonergic; Lysergic acid diethylamide; Dissociative; Major depressive disorder; Hallucinogen; Depression (economics); Mood; Psychiatry; Bipolar disorder; Clinical psychology; Neuroscience; Medicine; Internal medicine; Serotonin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001304385,0.0006568563,0.004411194,0.002528806,0.0002276128,0.00109007,0.000802449,0.0009811022,0.002522087],"category_scores_gemma":[0.00544282,0.000502841,0.004683416,0.002553596,0.0004309782,0.0007341278,0.000790213,0.00059747,0.0001789851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005989042,"about_ca_system_score_gemma":0.001475568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00405836,"about_ca_topic_score_gemma":0.01648601,"domain_scores_codex":[0.9992135,0.000175454,0.0003164996,0.0001187025,0.0001454458,0.00003042413],"domain_scores_gemma":[0.9971147,0.001754272,0.0008268037,0.00005062005,0.0002097335,0.00004395556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.002006373,0.00009370138,0.00439321,0.7688154,0.03746144,0.000171305,0.0001603312,0.0001665809,0.001072808,0.0001856673,0.002115041,0.1833581],"study_design_scores_gemma":[0.002937057,0.002038747,0.07444342,0.3523676,0.5071528,0.001599244,0.0008898528,0.0002978545,0.001126814,0.0007023429,0.05621495,0.0002294332],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001602437,0.9980415,0.00004135001,0.00004257193,0.00002913999,0.00003444517,0.00011823,0.000002188206,0.00008810657],"genre_scores_gemma":[0.02192753,0.9772007,0.0003002054,0.0002722963,0.00004166372,0.00005379914,0.000121154,0.000001920346,0.00008063085],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004411194,"threshold_uncertainty_score":0.008437216,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01611132175417918,"score_gpt":0.3400223724183668,"score_spread":0.3239110506641876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}