{"id":"W4393375305","doi":"10.1097/tp.0000000000004985","title":"Efficacy and Safety of Bleselumab in Preventing the Recurrence of Primary Focal Segmental Glomerulosclerosis in Kidney Transplant Recipients: A Phase 2a, Randomized, Multicenter Study","year":2024,"lang":"en","type":"article","venue":"Transplantation","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of British Columbia","funders":"Astellas Pharma Global Development; Astellas Pharma; Renal Pathology Society; National Heart, Lung, and Blood Institute; Sanofi","keywords":"Medicine; Focal segmental glomerulosclerosis; Immunosuppression; Basiliximab; Kidney transplantation; Transplantation; Clinical endpoint; Internal medicine; Kidney disease; Urology; Tacrolimus; Confidence interval; Adverse effect; Creatinine; Gastroenterology; Surgery; Proteinuria; Randomized controlled trial; Kidney","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007309929,0.0001358827,0.0004710087,0.0001965034,0.00002387951,0.00001120164,0.00005437631,0.00003911353,0.00001909918],"category_scores_gemma":[0.00004079448,0.00009200953,0.0001034114,0.0003137597,0.0001163531,0.0001259386,0.000006875764,0.0001522072,8.120461e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004085511,"about_ca_system_score_gemma":0.00006646951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002619285,"about_ca_topic_score_gemma":0.00007234935,"domain_scores_codex":[0.9983893,0.0002645186,0.0006873809,0.0002363916,0.0002751905,0.000147187],"domain_scores_gemma":[0.9993652,0.0003619666,0.0000808678,0.0001043787,0.00002350755,0.00006405106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5480028,0.007681696,0.2667654,0.0133751,0.0005851464,0.0002709436,0.07490855,0.00009294298,0.02473458,0.0001186317,0.0000119079,0.06345231],"study_design_scores_gemma":[0.2891619,0.0006567628,0.6893705,0.01387909,0.001095882,0.00001902066,0.0009378994,0.002709895,0.001994932,0.00002355947,0.00000415156,0.0001463565],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954116,0.001777637,0.0003497487,0.0001113923,0.00008449185,0.001927514,0.0002301543,0.00001208288,0.00009535035],"genre_scores_gemma":[0.9944437,0.005176776,0.00009642338,0.00002795017,0.00001327551,0.00006960417,0.0001534899,0.00001060579,0.000008193965],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4226052,"threshold_uncertainty_score":0.375204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01541259721674149,"score_gpt":0.295289732504433,"score_spread":0.2798771352876915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}