{"id":"W4393375305","doi":"10.1097/tp.0000000000004985","title":"Efficacy and Safety of Bleselumab in Preventing the Recurrence of Primary Focal Segmental Glomerulosclerosis in Kidney Transplant Recipients: A Phase 2a, Randomized, Multicenter Study","year":2024,"lang":"en","type":"article","venue":"Transplantation","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of British Columbia","funders":"Astellas Pharma Global Development; Astellas Pharma; Renal Pathology Society; National Heart, Lung, and Blood Institute; Sanofi","keywords":"Medicine; Focal segmental glomerulosclerosis; Immunosuppression; Basiliximab; Kidney transplantation; Transplantation; Clinical endpoint; Internal medicine; Kidney disease; Urology; Tacrolimus; Confidence interval; Adverse effect; Creatinine; Gastroenterology; Surgery; Proteinuria; Randomized controlled trial; Kidney","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003114782,0.001280164,0.00198407,0.0003290984,0.0003396115,0.001147876,0.0006127899,0.001401277,0.002516275],"category_scores_gemma":[0.001804721,0.0005177275,0.002300002,0.000274366,0.0008097829,0.0007312326,0.0003071545,0.002117724,0.0004091293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005523589,"about_ca_system_score_gemma":0.0008947324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004137783,"about_ca_topic_score_gemma":0.0007725033,"domain_scores_codex":[0.9989651,0.0005877747,0.00007662617,0.000158182,0.0001024944,0.0001098384],"domain_scores_gemma":[0.9982003,0.0005160405,0.0005808215,0.0001146041,0.0001217922,0.000466334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9495361,0.01462206,0.004511969,0.0006079859,0.002688883,0.00004367896,0.00006605039,0.0005286612,0.00552424,0.00005165857,0.0004246602,0.02139387],"study_design_scores_gemma":[0.7739299,0.2123527,0.009837607,0.00004769953,0.001502273,0.00008927684,0.00002667365,0.0007536208,0.001019668,0.00006069432,0.0003616179,0.00001830648],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956948,0.002746324,0.0002242128,0.0001677789,0.00009063802,0.0005450119,0.0001866959,0.0000263078,0.0003182393],"genre_scores_gemma":[0.9965444,0.001200065,0.0005135793,0.0003810079,0.0001876329,0.0005754619,0.0002590883,0.000007161274,0.0003316866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003114782,"threshold_uncertainty_score":0.0164727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01541259721674149,"score_gpt":0.295289732504433,"score_spread":0.2798771352876915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}