{"id":"W4393376807","doi":"10.1085/jgp.202313509","title":"Honeybee CaV4 has distinct permeation, inactivation, and pharmacology from homologous NaV channels","year":2024,"lang":"en","type":"article","venue":"The Journal of General Physiology","topic":"Insect and Pesticide Research","field":"Agricultural and Biological Sciences","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut Universitaire en Santé Mentale de Québec","funders":"Natural Sciences and Engineering Research Council of Canada; Université de Montpellier; Centre National de la Recherche Scientifique; Institut National de la Santé et de la Recherche Médicale; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; Agence Nationale de la Recherche","keywords":"Sodium channel; Divalent; Chemistry; Biophysics; Ion channel; Voltage-dependent calcium channel; Calcium; Voltage-gated ion channel; Calcium channel; Intracellular; Biochemistry; Permeation; Sodium; Biology; Membrane; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003522562,0.00009981432,0.000184547,0.00002282113,0.0002518754,0.00004926236,0.0002149018,0.00007558708,0.001066451],"category_scores_gemma":[0.00004109621,0.00003109185,0.00005659055,0.0001734476,0.0002222284,0.00009841226,0.0000650014,0.0002907361,0.00001779032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002627861,"about_ca_system_score_gemma":0.00003310126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007136718,"about_ca_topic_score_gemma":0.00006742567,"domain_scores_codex":[0.999005,0.0003396813,0.0002163592,0.0001157904,0.0001210522,0.0002020737],"domain_scores_gemma":[0.9990012,0.0006831054,0.00008965092,0.00002942113,0.0001339733,0.0000626246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001288496,0.00002257669,0.0001283529,0.000005115667,0.00005415078,0.00001269279,0.0002912477,0.0000500091,0.9834471,0.0001037263,0.007217811,0.00853841],"study_design_scores_gemma":[0.0007373401,0.003211793,0.6853009,0.00007978758,0.0002482283,0.0007457216,0.0005219262,0.005152971,0.1852956,0.07898708,0.03921766,0.0005009886],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915196,0.001847723,0.00002063789,0.005708807,0.0007042164,0.00007426385,0.000020217,0.00001268102,0.00009187587],"genre_scores_gemma":[0.9960075,0.0003920208,0.00001863358,0.0003013965,0.003047962,0.000002783207,0.00002172229,0.000001323863,0.0002066751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7981515,"threshold_uncertainty_score":0.9998467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03192433340582865,"score_gpt":0.2761591783391811,"score_spread":0.2442348449333524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}