{"id":"W4393376807","doi":"10.1085/jgp.202313509","title":"Honeybee CaV4 has distinct permeation, inactivation, and pharmacology from homologous NaV channels","year":2024,"lang":"en","type":"article","venue":"The Journal of General Physiology","topic":"Insect and Pesticide Research","field":"Agricultural and Biological Sciences","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut Universitaire en Santé Mentale de Québec","funders":"Natural Sciences and Engineering Research Council of Canada; Université de Montpellier; Centre National de la Recherche Scientifique; Institut National de la Santé et de la Recherche Médicale; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; Agence Nationale de la Recherche","keywords":"Sodium channel; Divalent; Chemistry; Biophysics; Ion channel; Voltage-dependent calcium channel; Calcium; Voltage-gated ion channel; Calcium channel; Intracellular; Biochemistry; Permeation; Sodium; Biology; Membrane; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007925434,0.0002229193,0.0003148483,0.0001982097,0.0001430789,0.0002560294,0.000192294,0.0002734924,0.0006753397],"category_scores_gemma":[0.0002259035,0.0001106263,0.0002584003,0.0001142291,0.0002859369,0.0003392227,0.0001945115,0.0002479725,0.0001615153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001817748,"about_ca_system_score_gemma":0.0001216005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005156118,"about_ca_topic_score_gemma":0.000410386,"domain_scores_codex":[0.9999255,0.000008971067,0.000008243187,0.00002350125,0.0000200352,0.0000138362],"domain_scores_gemma":[0.9999146,0.0000130175,0.00003176784,0.0000134361,0.00001375746,0.00001332837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001364601,0.000009429638,0.001855796,0.00003789793,0.000008844819,0.0001629062,0.00004054255,0.00007776129,0.994902,0.0001896388,0.00003327083,0.002545228],"study_design_scores_gemma":[0.000102477,0.0009776148,0.193575,0.00001833919,0.0001078318,0.007593733,0.0002401645,0.004630132,0.7838403,0.001239842,0.007618978,0.00005559701],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964419,0.000661387,0.00171348,0.00006494744,0.000009353043,0.00001308491,0.0001309668,0.00006081839,0.0009039816],"genre_scores_gemma":[0.9951313,0.0005255014,0.002026084,0.0000809868,0.00001528154,0.0000294305,0.0006059124,0.00003051608,0.001554999],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006753397,"threshold_uncertainty_score":0.002259254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03192433340582865,"score_gpt":0.2761591783391811,"score_spread":0.2442348449333524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}