{"id":"W4393377211","doi":"10.3390/curroncol31040140","title":"Exploration of Germline Correlates and Risk of Immune-Related Adverse Events in Advanced Cancer Patients Treated with Immune Checkpoint Inhibitors","year":2024,"lang":"en","type":"article","venue":"Current Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Pancreas Centre (Canada); Canada's Michael Smith Genome Sciences Centre","funders":"Genome British Columbia; Genome Canada","keywords":"Medicine; Adverse effect; Germline; Cancer; Human leukocyte antigen; Genetic predisposition; Family history; Pneumonitis; Oncology; Immune checkpoint; Internal medicine; Immune system; Immunotherapy; Immunology; Disease; Gene; Antigen; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002784567,0.0001266613,0.0002135342,0.0006842004,0.0002318033,0.0003608533,0.0001710952,0.0002015315,0.0011005],"category_scores_gemma":[0.001461161,0.0001026017,0.0001889644,0.0006855968,0.0001757581,0.0001946711,0.0002203411,0.0003144623,0.00009839376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001365895,"about_ca_system_score_gemma":0.0001615851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001251342,"about_ca_topic_score_gemma":0.001348346,"domain_scores_codex":[0.9997575,0.00006068821,0.00002610842,0.00005329212,0.00005010219,0.00005233662],"domain_scores_gemma":[0.99905,0.0002394238,0.0004429658,0.00004103542,0.00008879532,0.0001377946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00006097596,0.00001318257,0.9985948,0.000001866416,0.00001502037,0.00007227358,0.00001197344,0.00002923081,0.0002427371,0.000008986392,0.00001877313,0.0009300831],"study_design_scores_gemma":[0.000003896867,0.00009399209,0.9989296,0.000001806288,0.00001687942,0.0004116907,0.00007325265,0.0002035291,0.0001425743,0.00002453001,0.00009691175,0.000001366478],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994932,0.00009909624,0.0000471289,0.00001503782,0.000001637063,0.000002852636,0.00007771102,0.000001494671,0.0002618236],"genre_scores_gemma":[0.999777,0.00003949104,0.00003647082,0.0000100485,0.00000375281,0.000001832081,0.0000793993,9.077401e-7,0.00005116041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001251342,"threshold_uncertainty_score":0.0036816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02438653789645635,"score_gpt":0.3321608525211212,"score_spread":0.3077743146246648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}