{"id":"W4393386550","doi":"10.1084/jem.20231044","title":"Helper T cell immunity in humans with inherited CD4 deficiency","year":2024,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill Genome Centre","funders":"National Institute of Allergy and Infectious Diseases; Medical Research Council; Agence Nationale de la Recherche; Fondation Bettencourt Schueller; Institut National de la Santé et de la Recherche Médicale; Institut National Du Cancer; University of New South Wales; Honjo International Scholarship Foundation; Rockefeller University; National Health and Medical Research Council; Institut des maladies génétiques Imagine; Baxalta; American Association of Immunologists; St. Giles Foundation","keywords":"CD8; Biology; Immunity; Immunology; Immune system; Human leukocyte antigen; Cellular immunity; Antigen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008409531,0.0001689302,0.000289576,0.0002107282,0.0001623617,0.000009618972,0.0003898152,0.00007591109,0.0008108892],"category_scores_gemma":[0.00002397943,0.00008531206,0.00005729623,0.0003633482,0.0006108026,0.0001373135,0.00004996004,0.0006785931,0.00005725812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006265869,"about_ca_system_score_gemma":0.00007197033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002671319,"about_ca_topic_score_gemma":0.000003961125,"domain_scores_codex":[0.9988127,0.0002488717,0.0004796294,0.0001011871,0.00009357133,0.0002640145],"domain_scores_gemma":[0.9994529,0.0001582859,0.0001317981,0.0002053437,0.00004359924,0.000008004733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000370148,0.0003077954,0.0001175753,0.00001769789,0.00003842607,0.00003438977,0.02186788,0.00001793192,0.9757877,0.0002269393,0.0003652964,0.00084822],"study_design_scores_gemma":[0.008386698,0.007278175,0.01160177,0.001888825,0.0002127893,0.001668362,0.1618793,0.00002463741,0.7815887,0.0002312141,0.02473353,0.0005060419],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7053525,0.2898746,0.00004915961,0.0004394357,0.000622365,0.00009235585,9.48518e-7,0.00001390157,0.003554715],"genre_scores_gemma":[0.9986632,0.0004743031,0.000007741648,0.0001965592,0.00001320044,0.000003122457,0.000005735461,0.00001603254,0.0006200418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2933108,"threshold_uncertainty_score":0.8878668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01208116845924242,"score_gpt":0.2624187682036326,"score_spread":0.2503375997443902,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}