{"id":"W4393386927","doi":"10.3390/psychoactives3020012","title":"Orally Administered N-Oleoyl Alanine Blocks Acute Opioid Withdrawal Induced-Conditioned Place Preference and Attenuates Somatic Withdrawal following Chronic Opioid Exposure in Rats","year":2024,"lang":"en","type":"article","venue":"Psychoactives","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; Hebrew University of Jerusalem","keywords":"Conditioned place preference; Opioid; Pharmacology; Somatic cell; Medicine; Preference; Alanine; Morphine; Anesthesia; Internal medicine; Chemistry; Receptor; Amino acid; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002992118,0.0004046768,0.0005873811,0.0004310495,0.0001533329,0.0002558238,0.0001942948,0.0002085705,0.0002301051],"category_scores_gemma":[0.00006701119,0.0003389954,0.0001499733,0.0005919763,0.0001507869,0.0004433779,0.00009652826,0.0007544895,0.00003659604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000254856,"about_ca_system_score_gemma":0.0007695039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000750206,"about_ca_topic_score_gemma":0.0001974746,"domain_scores_codex":[0.9973673,0.0001048116,0.0004719155,0.000836194,0.000586741,0.000633102],"domain_scores_gemma":[0.9990063,0.00006732715,0.00008603078,0.0004310027,0.00008932913,0.0003199791],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003772621,0.001470159,0.08348721,0.003342843,0.0029519,0.002851798,0.02321979,0.00001385588,0.8111054,0.0004401472,0.01627541,0.05106887],"study_design_scores_gemma":[0.0186111,0.01261489,0.8445464,0.009618009,0.001183451,0.001514698,0.006812393,0.004364435,0.0842071,0.002010979,0.01208176,0.002434837],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886516,0.003793715,0.0000439463,0.004287008,0.0004374381,0.001097597,0.00004755543,0.0001506007,0.001490567],"genre_scores_gemma":[0.9916307,0.0002289668,0.0001790644,0.0001396153,0.0003171189,0.0003402127,0.00009330417,0.00006925009,0.007001798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7610592,"threshold_uncertainty_score":0.9999062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.019462817162129,"score_gpt":0.3126569268424739,"score_spread":0.2931941096803449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}