{"id":"W4393389014","doi":"10.1111/mmi.15256","title":"<i>Streptococcus pyogenes</i> Cas9 ribonucleoprotein delivery for efficient, rapid and marker‐free gene editing in <i>Trypanosoma</i> and <i>Leishmania</i>","year":2024,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval","funders":"Université de Bordeaux; Canadian Institutes of Health Research; Centre National de la Recherche Scientifique; Fondation pour la Recherche Médicale; Agence Nationale de la Recherche","keywords":"Biology; Cas9; Trypanosoma cruzi; Trypanosoma brucei; CRISPR; Genome editing; Leishmania; Virology; Plasmid; Kinetoplastida; Genome; Guide RNA; Gene; Genetics; Parasite hosting","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007132239,0.0002546576,0.0003737918,0.0002687425,0.0001125732,0.00007217326,0.0001539773,0.0002245569,0.00003621072],"category_scores_gemma":[0.0001321548,0.0002394292,0.0001107292,0.0003068268,0.0003015762,0.00004522539,0.0002713777,0.0002876805,0.00001353422],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007387534,"about_ca_system_score_gemma":0.0001157729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000424062,"about_ca_topic_score_gemma":0.00003815077,"domain_scores_codex":[0.9981385,0.00008173003,0.0003614787,0.0007208439,0.00007783975,0.0006195351],"domain_scores_gemma":[0.9990866,0.0001337591,0.0000461892,0.0004469311,0.00009547159,0.0001910057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001108976,0.00006942634,0.0008134531,0.0002679269,0.00007565323,0.000256974,0.00005053668,0.000002171329,0.9832258,0.0003678872,0.004417369,0.01034189],"study_design_scores_gemma":[0.004396577,0.0007875516,0.0144133,0.0003016211,0.0001335744,0.002707724,0.0001152112,0.001100161,0.7661967,0.0002384858,0.2090963,0.0005127363],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9699625,0.02330236,0.001573166,0.0022834,0.0001577368,0.001594718,0.0005180663,0.00010282,0.0005052278],"genre_scores_gemma":[0.9936232,0.0005118006,0.003502933,0.001288504,0.0001998401,0.0003530252,0.0002733298,0.00006895157,0.0001784011],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2170291,"threshold_uncertainty_score":0.976364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009231545040324935,"score_gpt":0.2504162131641317,"score_spread":0.2411846681238068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}