{"id":"W4393392723","doi":"10.1038/s41416-024-02638-2","title":"Genetic risk impacts the association of menopausal hormone therapy with colorectal cancer risk","year":2024,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Menopause: Health Impacts and Treatments","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; Faculty of Medicine and Health, University of Sydney; Wallenberg Centre for Molecular and Translational Medicine; School of Public Health, Imperial College London; National Health and Medical Research Council; Canadian Cancer Society Research Institute; Johns Hopkins Bloomberg School of Public Health; National Institutes of Health; Deutschen Konsortium für Translationale Krebsforschung; Canadian Institutes of Health Research; Technion-Israel Institute of Technology; Universitat de Barcelona; Tokyo Medical and Dental University; Deutsches Krebsforschungszentrum; Clalit Health Services; Binus University; Massey University; Umeå Universitet; Harvard T.H. Chan School of Public Health; Karolinska Institutet; Memorial University of Newfoundland; Imperial College London; University of Toronto; Ministerio de Economía y Competitividad; Vetenskapsrådet; National Natural Science Foundation of China; Monash University; Génome Québec; Medical Center, University of Pittsburgh; City of Hope; World Health Organization; Cedars-Sinai Medical Center; School of Public Health, University of Michigan; Swedish Cancer Foundation; American Cancer Society; University of Ioannina; Kaiser Permanente Washington Health Research Institute; Johns Hopkins University; Centre International de Recherche sur le Cancer; Capital Medical University; Division of Cancer Epidemiology and Genetics, National Cancer Institute; Huntsman Cancer Institute; University of Leeds; McGill University; Division of Cancer Prevention, National Cancer Institute; University of Pittsburgh; University of Washington; Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina at Chapel Hill; University of Texas MD Anderson Cancer Center; Centers for Disease Control and Prevention; Cancer Council Victoria; University of Melbourne; University of North Carolina at Chapel Hill; Harvard University; Brigham and Women's Hospital; National Center for Advancing Translational Sciences; Kaiser Permanente; Broad Institute; Wageningen University and Research; Cancer Research UK; University of Southern California; Massachusetts General Hospital; U.S. Department of Health and Human Services","keywords":"Quartile; Medicine; Odds ratio; Internal medicine; Logistic regression; Colorectal cancer; Absolute risk reduction; Relative risk; Menopause; Oncology; Cancer; Gynecology; Demography; Confidence interval","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006622265,0.0003164849,0.0002715041,0.0005247826,0.0002470302,0.0006065628,0.000235022,0.0004278529,0.002978457],"category_scores_gemma":[0.003061849,0.0001895426,0.0008344424,0.0006911653,0.0003457229,0.0001857834,0.0003330637,0.0003837226,0.0001840306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000163011,"about_ca_system_score_gemma":0.0002858407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003978189,"about_ca_topic_score_gemma":0.002474624,"domain_scores_codex":[0.9990544,0.0005061372,0.00005602706,0.0002107745,0.00008896778,0.00008382846],"domain_scores_gemma":[0.9980766,0.001037157,0.0004920314,0.0001491763,0.00007403406,0.0001711022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007495335,0.00005234773,0.9875377,0.00003104225,0.0008101889,0.0002321215,0.00006583294,0.0003784474,0.004916303,0.0001564441,0.0001413385,0.004928801],"study_design_scores_gemma":[0.00001311181,0.0001114245,0.9974475,0.000007476475,0.0002955246,0.0002923461,0.00003635432,0.0009041918,0.0003631359,0.0002257163,0.000297741,0.000005429348],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959902,0.001590739,0.000710595,0.0002786464,0.00002301619,0.000007886128,0.0003669279,0.00002163742,0.001010453],"genre_scores_gemma":[0.9993379,0.0001628491,0.0002031646,0.00003134358,0.0000137888,0.000002209307,0.00006797411,0.00000432797,0.0001764061],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003978189,"threshold_uncertainty_score":0.00996387,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01179583640862956,"score_gpt":0.3085199928284912,"score_spread":0.2967241564198616,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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