{"id":"W4393397077","doi":"10.1038/s41598-024-58285-3","title":"Identification and structural characterization of small molecule inhibitors of PINK1","year":2024,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Structural Genomics Consortium","funders":"National Institute of Neurological Disorders and Stroke; Office of Science; National Institutes of Health; Canadian Institutes of Health Research; Parkinson Canada; U.S. Department of Energy; McGill University; Argonne National Laboratory; Fonds de Recherche du Québec - Santé; Michael J. Fox Foundation for Parkinson's Research","keywords":"PINK1; Parkin; Cell biology; Ubiquitin ligase; Autophosphorylation; Ubiquitin; Mitophagy; Mitochondrion; Organelle; Biology; Phosphorylation; Kinase; Biochemistry; Chemistry; Protein kinase A; Autophagy; Parkinson's disease; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024017,0.0005625471,0.000465492,0.0004106649,0.0002063103,0.0003068808,0.0005118369,0.0003181057,0.001592436],"category_scores_gemma":[0.0002427861,0.0003124776,0.0004515822,0.0003124171,0.0001728833,0.0002155456,0.0001800793,0.0006721616,0.0005628475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000481571,"about_ca_system_score_gemma":0.0003183138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009413981,"about_ca_topic_score_gemma":0.001180946,"domain_scores_codex":[0.9998614,0.00002011391,0.00001152781,0.00002429727,0.00005233522,0.00003028872],"domain_scores_gemma":[0.9998828,0.00002301729,0.00002636988,0.00000894086,0.00002888871,0.00003004601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003404459,0.0003272684,0.0002984722,0.0001631484,0.00007052942,0.0002120601,0.00003005822,0.00338338,0.9866301,0.0004001142,0.000519353,0.007625045],"study_design_scores_gemma":[0.0003957025,0.002856959,0.001899387,0.00002171867,0.0001108346,0.0007425762,0.00002307704,0.00796183,0.9761261,0.00009771559,0.009738474,0.00002574931],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.971821,0.01135135,0.007322758,0.0003653632,0.00008252235,0.0004852616,0.002175104,0.0002040133,0.006192658],"genre_scores_gemma":[0.9732156,0.006972575,0.008978978,0.0002591363,0.00002533149,0.0001877384,0.005368219,0.00004758038,0.004944904],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001592436,"threshold_uncertainty_score":0.005327225,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009320992698905855,"score_gpt":0.2610250255650896,"score_spread":0.2517040328661837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}