{"id":"W4393427136","doi":"10.1038/s41598-024-57707-6","title":"Key HPI axis receptors facilitate light adaptive behavior in larval zebrafish","year":2024,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Zebrafish Biomedical Research Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Mayo Clinic","keywords":"Zebrafish; Glucocorticoid receptor; Biology; Context (archaeology); Mineralocorticoid receptor; Receptor; Darkness; Neuroscience; Basal (medicine); Mineralocorticoid; Adaptation (eye); Cell biology; Hypothalamic–pituitary–adrenal axis; Glucocorticoid; Endocrinology; Internal medicine; Genetics; Medicine; Hormone; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001370458,0.0001555865,0.0001379056,0.0002295446,0.0001323515,0.0002480182,0.0002372582,0.0001610996,0.0002645676],"category_scores_gemma":[0.0004374437,0.0001405775,0.0001277715,0.0007984255,0.0004020372,0.00001568105,0.0002137461,0.0002126913,0.0002276833],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000649959,"about_ca_system_score_gemma":0.0004273451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005737748,"about_ca_topic_score_gemma":0.0003289674,"domain_scores_codex":[0.997341,0.00007048562,0.0004293605,0.001122018,0.0005717212,0.0004654037],"domain_scores_gemma":[0.9987271,0.00002098582,0.0000562742,0.0007948922,0.0001363631,0.0002643653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002102361,0.0001651885,0.00178161,0.00002813799,0.00002921295,0.0005363978,0.0002114726,0.000003356354,0.78703,0.0001048466,0.2002006,0.00988807],"study_design_scores_gemma":[0.000080289,0.0001007097,0.001153943,0.00003054784,0.000009206957,0.00007856212,0.0000887507,0.00006199504,0.16354,0.00117007,0.8335045,0.0001813838],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877706,0.001227234,0.0003643415,0.001185532,0.00405839,0.00081257,0.00004432869,0.00008488047,0.004452095],"genre_scores_gemma":[0.9772875,0.00003117658,0.0006349516,0.00003787014,0.0001375627,0.0003544646,0.000412285,0.00002618378,0.02107795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6333039,"threshold_uncertainty_score":0.5732584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02028807305505972,"score_gpt":0.2897685826324495,"score_spread":0.2694805095773898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}