{"id":"W4393428140","doi":"10.1172/jci.insight.176556","title":"Impaired innate and adaptive immune responses to BNT162b2 SARS-CoV-2 vaccination in systemic lupus erythematosus","year":2024,"lang":"en","type":"article","venue":"JCI Insight","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Environmental Health Sciences; National Institute of Allergy and Infectious Diseases; Stanford Bio-X; National Science Foundation; Damon Runyon Cancer Research Foundation; Open Philanthropy Project; NIH Clinical Center; Harvard T.H. Chan School of Public Health; Bill and Melinda Gates Foundation; National Heart, Lung, and Blood Institute; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; U.S. Department of Defense; National Cancer Institute","keywords":"Immunology; Medicine; Immune system; Vaccination; Innate immune system; CXCL10; Chemokine; Acquired immune system; Population; CXCL9; IRF7","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002177171,0.0002868426,0.0003151613,0.0001509884,0.0001344357,0.0002198882,0.00005562477,0.000199264,0.001108395],"category_scores_gemma":[0.0001828642,0.0001109437,0.0001648846,0.0001037093,0.0001661924,0.0001516113,0.0001350493,0.0003198192,0.0002016372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001416809,"about_ca_system_score_gemma":0.0001408819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003438621,"about_ca_topic_score_gemma":0.000417747,"domain_scores_codex":[0.999876,0.00003712558,0.00001279293,0.00003261401,0.00001746308,0.00002399903],"domain_scores_gemma":[0.9999022,0.00001651215,0.00003727517,0.000008318792,0.000009887793,0.00002572299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002594187,0.0002212718,0.1061714,0.000144088,0.0000550991,0.001035216,0.0001940768,0.0003706812,0.872685,0.00005769217,0.0002860948,0.01618538],"study_design_scores_gemma":[0.0002157494,0.005415382,0.8584981,0.00003854607,0.0001549542,0.007282156,0.0003464248,0.002228585,0.1226753,0.000151298,0.002975753,0.00001765832],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990767,0.0003362699,0.0001903636,0.00002641439,0.000003614651,0.000007531129,0.0001050768,0.000007352357,0.0002466607],"genre_scores_gemma":[0.9991091,0.0001846473,0.0001965507,0.00005248746,0.000006670779,0.00001012788,0.0001793339,0.000003089785,0.0002579727],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001108395,"threshold_uncertainty_score":0.003708005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04830833859781974,"score_gpt":0.3446695551771252,"score_spread":0.2963612165793054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}