{"id":"W4393428140","doi":"10.1172/jci.insight.176556","title":"Impaired innate and adaptive immune responses to BNT162b2 SARS-CoV-2 vaccination in systemic lupus erythematosus","year":2024,"lang":"en","type":"article","venue":"JCI Insight","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Environmental Health Sciences; National Institute of Allergy and Infectious Diseases; Stanford Bio-X; National Science Foundation; Damon Runyon Cancer Research Foundation; Open Philanthropy Project; NIH Clinical Center; Harvard T.H. Chan School of Public Health; Bill and Melinda Gates Foundation; National Heart, Lung, and Blood Institute; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; U.S. Department of Defense; National Cancer Institute","keywords":"Immunology; Medicine; Immune system; Vaccination; Innate immune system; CXCL10; Chemokine; Acquired immune system; Population; CXCL9; IRF7","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006238374,0.0002491075,0.0004600685,0.001057654,0.00006749955,0.0001143371,0.0001428621,0.0001772153,0.000006847865],"category_scores_gemma":[0.000380264,0.0002038949,0.00009068315,0.001152538,0.00004012337,0.0002295055,0.0001510116,0.000383957,0.0002173434],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004334172,"about_ca_system_score_gemma":0.0003530864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003125873,"about_ca_topic_score_gemma":0.0001337623,"domain_scores_codex":[0.9979644,0.0001780325,0.0004739383,0.0005247303,0.0004444311,0.0004144752],"domain_scores_gemma":[0.9990216,0.0003309523,0.00004889974,0.0003908811,0.0001591002,0.00004858317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003470463,0.0001862149,0.01317837,0.0009711483,0.0001448508,0.002140245,0.008731728,5.70124e-7,0.95731,0.001938957,0.001873433,0.01005405],"study_design_scores_gemma":[0.004841824,0.001891188,0.02669259,0.003355979,0.0001149177,0.004040567,0.00156234,0.004974495,0.8406812,0.0008679482,0.1102814,0.0006955943],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842992,0.009749396,0.0001327777,0.0009340229,0.0004470019,0.001025353,0.00001111159,0.000193095,0.003207986],"genre_scores_gemma":[0.995259,0.00004541478,0.00009156986,0.003896168,0.0001289061,0.0001661736,0.000003668104,0.00005355105,0.0003555159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1166288,"threshold_uncertainty_score":0.8314591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04830833859781974,"score_gpt":0.3446695551771252,"score_spread":0.2963612165793054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}