{"id":"W4393443897","doi":"10.1038/s41380-024-02531-7","title":"Pharmacological fingerprint of antipsychotic drugs at the serotonin 5-HT2A receptor","year":2024,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Psychedelics and Drug Studies","field":"Psychology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"National Institute of Mental Health; National Institutes of Health; Instituto de Salud Carlos III; Canadian Institutes of Health Research; Mitacs; Bundesministerium für Bildung und Forschung; European Regional Development Fund; Deutsche Forschungsgemeinschaft; European Commission","keywords":"Serotonin; Antipsychotic; Schizophrenia (object-oriented programming); 5-HT receptor; Pharmacology; Psychology; Serotonin syndrome; Neuroscience; Medicine; Psychiatry; Receptor; Serotonergic; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0004685007,0.0002837522,0.0002991509,0.0001075244,0.0001632111,0.00004161414,0.0004359353,0.0001343411,0.003269305],"category_scores_gemma":[0.00001312143,0.0001936435,0.0003532351,0.0004698244,0.0002461803,0.00002822031,0.0001762569,0.0003897316,0.001350456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004367651,"about_ca_system_score_gemma":0.00005683484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002734064,"about_ca_topic_score_gemma":0.000009767125,"domain_scores_codex":[0.9979471,0.0002083987,0.0004530174,0.0006257542,0.0003126296,0.0004530742],"domain_scores_gemma":[0.9990516,0.0001195626,0.00009920263,0.0005875406,0.00004955577,0.00009247907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000636876,0.00114928,0.007661568,0.0002972833,0.00277625,0.0001167573,0.006069868,0.0000725277,0.0662835,0.2030381,0.6968526,0.01504545],"study_design_scores_gemma":[0.00466582,0.001070753,0.02682049,0.0006886717,0.001074258,0.0002533999,0.005124846,0.0005361693,0.02482422,0.02786827,0.9049795,0.002093621],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8706741,0.04518424,0.0005843168,0.01608044,0.01133409,0.0005828674,0.00004285415,0.0001813244,0.05533579],"genre_scores_gemma":[0.9929031,0.0002329851,0.0006093602,0.001969812,0.000311278,0.0001749838,0.00001110094,0.00005714914,0.003730256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2081269,"threshold_uncertainty_score":0.9994271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0138276310481847,"score_gpt":0.3312150377641493,"score_spread":0.3173874067159646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}