{"id":"W4393525906","doi":"10.1002/ana.26923","title":"Alterations in Blood Methylome as Potential Epigenetic Biomarker in Sporadic Parkinson's Disease","year":2024,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Avid Radiopharmaceuticals; Allergan; GE Healthcare; Sun Pharma; H. Lundbeck A/S; Servier; Voyager Therapeutics; Bristol-Myers Squibb; Aligning Science Across Parkinson’s; AbbVie; Denali Therapeutics; Neurocrine Biosciences; Roche; Biohaven Pharmaceuticals; Celgene; Pfizer; Biogen; Genentech; Weston Family Foundation; Merck; GlaxoSmithKline; Cerevel Therapeutics; Eli Lilly and Company; Michael J. Fox Foundation for Parkinson's Research; Verily Life Sciences; Teva Pharmaceutical Industries; Amathus Therapeutics; Sanofi; UCB","keywords":"Epigenetics; DNA methylation; Methylation; Biology; Biomarker; dNaM; Gene; Gene expression; Genetics; Molecular biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002427181,0.0001654603,0.0002693115,0.0006018273,0.0001671291,0.0002131028,0.0001268709,0.00025573,0.0008473623],"category_scores_gemma":[0.0006662818,0.00008404171,0.0001017808,0.000473469,0.0001099297,0.0001402067,0.0001831791,0.0001699289,0.0001193797],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001815243,"about_ca_system_score_gemma":0.00009907693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008968026,"about_ca_topic_score_gemma":0.001510201,"domain_scores_codex":[0.9998863,0.00002397485,0.00001133617,0.00003640392,0.00002779384,0.00001419479],"domain_scores_gemma":[0.9997817,0.00004712043,0.00009198313,0.00001242478,0.00003926545,0.00002752897],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00132203,0.00006529033,0.9084867,0.00008457516,0.0001051311,0.0002213737,0.000153938,0.0001736562,0.07256446,0.00004064724,0.0002157627,0.01656655],"study_design_scores_gemma":[0.00001255916,0.0004041793,0.9912794,0.000009072607,0.00004143414,0.0005081423,0.00007914028,0.0004206367,0.006638406,0.00005744859,0.0005457639,0.000003807532],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976017,0.001010362,0.0003834565,0.00003565246,0.000004627164,0.000009132308,0.0006315176,0.00001297627,0.0003104831],"genre_scores_gemma":[0.9984856,0.0002210579,0.0005221915,0.00003176761,0.000008220224,0.00001154905,0.0004578365,0.000002322919,0.0002593906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008968026,"threshold_uncertainty_score":0.002834737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02776220565474603,"score_gpt":0.3159231477545569,"score_spread":0.2881609420998109,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}