{"id":"W4393855135","doi":"10.1128/aac.01533-23","title":"Opportunistic dried blood spot sampling validates and optimizes a pediatric population pharmacokinetic model of metronidazole","year":2024,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antibiotics Pharmacokinetics and Efficacy","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital Research Institute of Manitoba; Centre Hospitalier Universitaire Sainte-Justine","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Child Health and Human Development; Penn State College of Medicine; University of North Carolina at Chapel Hill; National Institutes of Health; Connecticut Children's Medical Center; Loma Linda University; Childhood Arthritis and Rheumatology Research Alliance; Purdue Pharma; Wichita Medical Research and Education Foundation; Tufts Medical Center; Pennsylvania State University; National Institute of Allergy and Infectious Diseases; Indiana University Health; Vanderbilt University Medical Center; University of Louisville; University of Minnesota; Duke Clinical Research Institute; Cincinnati Children's Hospital Medical Center; Purdue University; University of Oklahoma; University of Texas Health Science Center at Houston; Pfizer; Biogen; Centers for Disease Control and Prevention; University of Pennsylvania; Vanderbilt University; Children's Hospital of Philadelphia; National Institute of General Medical Sciences; East Carolina University","keywords":"Metronidazole; Dosing; Gestational age; Medicine; Pharmacokinetics; Population; Volume of distribution; Pediatrics; Anesthesia; Antibiotics; Internal medicine; Pregnancy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003753564,0.00081553,0.0008609827,0.0003396989,0.0002229429,0.001159117,0.0006749958,0.0004842669,0.0006806143],"category_scores_gemma":[0.007768236,0.0004476191,0.0007639297,0.0003551868,0.0003256295,0.0004776981,0.0004808144,0.0008302147,0.0003125845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008683988,"about_ca_system_score_gemma":0.002011694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01174438,"about_ca_topic_score_gemma":0.008065318,"domain_scores_codex":[0.9986986,0.0007308414,0.00005586781,0.0002663909,0.0001823806,0.00006591205],"domain_scores_gemma":[0.9974801,0.001668276,0.0003487103,0.0001993287,0.0002575332,0.00004595701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001631147,0.0004115731,0.1410454,0.0002961765,0.00080952,0.0003425222,0.0002669502,0.7459243,0.02335534,0.002611042,0.002159769,0.08114635],"study_design_scores_gemma":[0.0001096264,0.0007705807,0.01451208,0.00002378909,0.0001493489,0.0001701157,0.00004948964,0.9737014,0.007049272,0.001046534,0.002384806,0.00003296859],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.719128,0.0007643976,0.2741363,0.000287686,0.00003767686,0.0002943628,0.001338328,0.0007914365,0.003221869],"genre_scores_gemma":[0.9398388,0.0004579521,0.0573451,0.0001954787,0.00002156166,0.0001711773,0.001216432,0.000111034,0.0006425317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01174438,"threshold_uncertainty_score":0.02335203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03857439994134209,"score_gpt":0.3168233735896664,"score_spread":0.2782489736483243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}