{"id":"W4393858481","doi":"10.1016/j.ekir.2024.03.032","title":"The Efficacy and Safety of Reduced-Dose Oral Methylprednisolone in High-Risk Immunoglobulin A Nephropathy","year":2024,"lang":"en","type":"article","venue":"Kidney International Reports","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University Health Network; Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"Chinese Academy of Medical Sciences Initiative for Innovative Medicine; Medical Research Council; National Key Research and Development Program of China; Peking University; Canadian Institutes of Health Research; Chinese Academy of Medical Sciences; Peking University First Hospital; National Health and Medical Research Council; Pfizer","keywords":"Medicine; Methylprednisolone; Proteinuria; Renal function; Placebo; Adverse effect; Nephropathy; Kidney disease; Internal medicine; Regimen; Urology; Kidney; Endocrinology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002710335,0.0004865496,0.001337265,0.0002647909,0.0001430962,0.0006481113,0.0005850914,0.001001991,0.001991475],"category_scores_gemma":[0.002578753,0.00017543,0.001642675,0.0002866384,0.0005112109,0.0003111736,0.0002711383,0.001286781,0.0002355896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000640697,"about_ca_system_score_gemma":0.000508352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006081365,"about_ca_topic_score_gemma":0.001108905,"domain_scores_codex":[0.9985643,0.0008827189,0.0001059741,0.0001059396,0.0002054571,0.0001357049],"domain_scores_gemma":[0.9981418,0.0008180913,0.0005486623,0.0001158076,0.0001284669,0.0002472154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8328466,0.003576422,0.01335177,0.002087363,0.003609957,0.0001249164,0.00008045571,0.0008214121,0.007042278,0.0001433436,0.0006576045,0.1356578],"study_design_scores_gemma":[0.5076874,0.3646717,0.110832,0.0006288485,0.005043554,0.0004203202,0.00009503021,0.001345969,0.004807148,0.0006584562,0.003747136,0.00006231121],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9781162,0.01992296,0.0001773061,0.0004023359,0.0001442287,0.0001640503,0.0003089313,0.00001562741,0.0007483496],"genre_scores_gemma":[0.9955775,0.003362405,0.0001591696,0.0001892798,0.0001577519,0.00007417252,0.0002006437,0.000002356004,0.0002767376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002710335,"threshold_uncertainty_score":0.01433384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008244400354706529,"score_gpt":0.2840366098637607,"score_spread":0.2757922095090541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}