{"id":"W4393859830","doi":"10.1002/adhm.202400235","title":"Antibody‐Conjugated Nanogel with Two Immune Checkpoint Inhibitors for Enhanced Cancer Immunotherapy","year":2024,"lang":"en","type":"article","venue":"Advanced Healthcare Materials","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nexen (Canada)","funders":"National Research Foundation of Korea","keywords":"Immunotherapy; Monoclonal antibody; Immune system; Antibody; Cancer research; Cancer; Cancer immunotherapy; Antigen; Medicine; Cancer cell; Breast cancer; Immunology; Cytotoxic T cell; Metastatic breast cancer; In vitro; Biology; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004776654,0.0004518924,0.0008619381,0.0001934766,0.0001658962,0.0001109992,0.0001385799,0.000169829,0.0002912271],"category_scores_gemma":[0.00001363899,0.00033837,0.0002235772,0.0004440544,0.0001471912,0.0002489981,0.00002505533,0.0001789887,0.0000155406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004303062,"about_ca_system_score_gemma":0.0006528888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001890022,"about_ca_topic_score_gemma":0.0002367414,"domain_scores_codex":[0.997245,0.00006501984,0.0009736374,0.0007053586,0.0003013844,0.0007095563],"domain_scores_gemma":[0.9987335,0.000078074,0.0002384329,0.0005132033,0.0002871569,0.0001496192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01969916,0.00005957903,0.00003521564,0.001610929,0.0003846054,0.00002483613,0.0006162095,0.000005851321,0.9285553,0.0001727735,0.00004666814,0.04878892],"study_design_scores_gemma":[0.008831806,0.001338796,0.0006797361,0.003020153,0.00007337867,0.0000568517,0.0001705051,0.000007328714,0.9472476,0.0001705298,0.03798952,0.0004137536],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9550878,0.02820444,0.001219228,0.007651903,0.003321803,0.003310175,0.0003295099,0.0007949505,0.00008014349],"genre_scores_gemma":[0.9863676,0.006308059,0.002542088,0.001330535,0.0006834829,0.001271553,0.0005326785,0.0002554944,0.0007084939],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04837517,"threshold_uncertainty_score":0.9999068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01587229500458322,"score_gpt":0.3596063736358575,"score_spread":0.3437340786312743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}