{"id":"W4393862200","doi":"10.1038/s41398-024-02865-4","title":"Immunogenetics of lithium response and psychiatric phenotypes in patients with bipolar disorder","year":2024,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Movement Disorders; McGill University; Douglas Mental Health University Institute; McGill University Health Centre; Dalhousie University; Montreal Neurological Institute and Hospital","funders":"National Health and Medical Research Council; Medical Research Council; Canadian Institutes of Health Research; National Institutes of Health; Research Nova Scotia; Genome Atlantic; The Wellcome Trust DBT India Alliance; Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii; Generalitat de Catalunya; Université de Genève; Hôpitaux Universitaires de Genève; Vetenskapsrådet; National Institute of Mental Health; Stockholms Läns Landsting; Dokkyo Medical University; Ministerstvo Školství, Mládeže a Tělovýchovy; Bundesministerium für Bildung und Forschung; Grantová Agentura České Republiky; Centro de Investigación Biomédica en Red de Salud Mental; National Alliance for Research on Schizophrenia and Depression; Karolinska Institutet; Institut National de la Santé et de la Recherche Médicale; Centres de Recerca de Catalunya; Deutsche Forschungsgemeinschaft; Instituto de Salud Carlos III; Universitat de Barcelona; Department of Biotechnology, Ministry of Science and Technology, India; Fondation FondaMental; U.S. Department of Veterans Affairs; University of New South Wales; Agence Nationale de la Recherche; Wellcome Trust; Brain and Behavior Research Foundation","keywords":"Bipolar disorder; Genome-wide association study; Schizophrenia (object-oriented programming); Genetic association; Psychosis; Lithium (medication); Disease; Genetic architecture; Mood disorders; Medicine; Immune system; Phenotype; Psychiatry; Genetics; Clinical psychology; Psychology; Internal medicine; Immunology; Single-nucleotide polymorphism; Biology; Gene; Genotype; Anxiety","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009412912,0.0001273091,0.0001566048,0.0002219389,0.0000293849,0.000009075407,0.0000313309,0.0000660563,0.00005092198],"category_scores_gemma":[0.000002630699,0.00009667031,0.00005032479,0.0003604639,0.00005641837,0.00005192637,0.00000422761,0.0001262748,0.00000611773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009360731,"about_ca_system_score_gemma":0.0001735762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002769865,"about_ca_topic_score_gemma":0.0001069231,"domain_scores_codex":[0.9991925,0.00003563198,0.0002247204,0.0002034751,0.0002244419,0.0001191846],"domain_scores_gemma":[0.9997175,0.00004606762,0.00002302598,0.0001319951,0.00003604388,0.0000453621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002658821,0.0005791305,0.9889022,0.0002061305,0.0001255386,4.39865e-7,0.0002588145,0.00001719399,0.00002832407,0.00148459,0.00001976295,0.005719128],"study_design_scores_gemma":[0.003026073,0.0006001656,0.9911315,0.0001139127,0.0001511075,0.000003904899,0.00002253535,0.00008249041,0.000007223406,0.001012308,0.003750257,0.00009854784],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8893176,0.1075453,0.0002381514,0.002117714,0.0001629151,0.0002944882,0.00005990457,0.00002449956,0.0002394063],"genre_scores_gemma":[0.9947051,0.0001363608,0.004926572,0.00003608682,0.00002977933,0.000007641934,0.00006326231,0.00002400545,0.00007118462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.107409,"threshold_uncertainty_score":0.3942101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005178579226286877,"score_gpt":0.2382072705707463,"score_spread":0.2330286913444594,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}