{"id":"W4393862200","doi":"10.1038/s41398-024-02865-4","title":"Immunogenetics of lithium response and psychiatric phenotypes in patients with bipolar disorder","year":2024,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Movement Disorders; McGill University; Douglas Mental Health University Institute; McGill University Health Centre; Dalhousie University; Montreal Neurological Institute and Hospital","funders":"National Health and Medical Research Council; Medical Research Council; Canadian Institutes of Health Research; National Institutes of Health; Research Nova Scotia; Genome Atlantic; The Wellcome Trust DBT India Alliance; Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii; Generalitat de Catalunya; Université de Genève; Hôpitaux Universitaires de Genève; Vetenskapsrådet; National Institute of Mental Health; Stockholms Läns Landsting; Dokkyo Medical University; Ministerstvo Školství, Mládeže a Tělovýchovy; Bundesministerium für Bildung und Forschung; Grantová Agentura České Republiky; Centro de Investigación Biomédica en Red de Salud Mental; National Alliance for Research on Schizophrenia and Depression; Karolinska Institutet; Institut National de la Santé et de la Recherche Médicale; Centres de Recerca de Catalunya; Deutsche Forschungsgemeinschaft; Instituto de Salud Carlos III; Universitat de Barcelona; Department of Biotechnology, Ministry of Science and Technology, India; Fondation FondaMental; U.S. Department of Veterans Affairs; University of New South Wales; Agence Nationale de la Recherche; Wellcome Trust; Brain and Behavior Research Foundation","keywords":"Bipolar disorder; Genome-wide association study; Schizophrenia (object-oriented programming); Genetic association; Psychosis; Lithium (medication); Disease; Genetic architecture; Mood disorders; Medicine; Immune system; Phenotype; Psychiatry; Genetics; Clinical psychology; Psychology; Internal medicine; Immunology; Single-nucleotide polymorphism; Biology; Gene; Genotype; Anxiety","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002717328,0.000239723,0.000295619,0.0006757114,0.0003596121,0.0003836782,0.0001544393,0.0002872725,0.00164972],"category_scores_gemma":[0.0007796832,0.0001083289,0.0002790401,0.0008207979,0.000207203,0.0001529273,0.0002519841,0.0003096038,0.0001810086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002016205,"about_ca_system_score_gemma":0.000122073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001808293,"about_ca_topic_score_gemma":0.002329423,"domain_scores_codex":[0.9997997,0.00006638654,0.00002409291,0.00004291243,0.00003844247,0.00002844457],"domain_scores_gemma":[0.9995065,0.00007847041,0.0002930493,0.0000250555,0.00003416685,0.0000628521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002852706,0.00002497766,0.9967324,0.00001058882,0.00005725782,0.0001240984,0.00003668704,0.00004718514,0.001178005,0.00001688788,0.00006925792,0.001417346],"study_design_scores_gemma":[0.000005592407,0.00005087714,0.9994243,0.000003207213,0.0000173675,0.0002054969,0.00004640827,0.0001186175,0.00005914941,0.00002926402,0.00003796158,0.000001690253],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992229,0.0001820493,0.00007127243,0.00003030693,0.000003107774,0.000004817796,0.0002127897,0.00000342387,0.0002692727],"genre_scores_gemma":[0.9996462,0.00004459188,0.00005555342,0.00001741503,0.000004559768,0.00000408811,0.0001717288,0.000001320344,0.00005457403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001808293,"threshold_uncertainty_score":0.005518794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005178579226286877,"score_gpt":0.2382072705707463,"score_spread":0.2330286913444594,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}