{"id":"W4393868677","doi":"10.1101/2024.04.02.587687","title":"Evolutionary insights into the emergence of virulent <i>Leptospira</i> spirochetes","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Leptospirosis research and findings","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Armand Frappier Museum; Institut National de la Recherche Scientifique","funders":"National Institutes of Health; Agence Nationale de la Recherche","keywords":"Leptospira; Virulence; Biology; Leptospirosis; Zoonosis; Spirochaete; Leptospira interrogans; Microbiology; Pathogen; Virology; Genetics; Bacteria; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003327229,0.0003915564,0.0002956959,0.0005197981,0.0003000892,0.0006622599,0.0002897655,0.0004965911,0.0009130638],"category_scores_gemma":[0.0002871127,0.0001433377,0.0002925157,0.000359112,0.0003058133,0.0003956008,0.0005022357,0.0005225988,0.0002749767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002955508,"about_ca_system_score_gemma":0.0002887314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007466705,"about_ca_topic_score_gemma":0.0008469377,"domain_scores_codex":[0.9998529,0.00003609762,0.000009562098,0.00004169342,0.00002266445,0.00003710808],"domain_scores_gemma":[0.9998193,0.00003278357,0.00005759664,0.00001749053,0.00003250522,0.00004032714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001754828,0.0000695417,0.05430675,0.0001581029,0.00004914334,0.0007530277,0.0003459803,0.000990451,0.9262678,0.001100363,0.0001614518,0.01562188],"study_design_scores_gemma":[0.00003411176,0.001252273,0.8730738,0.000155717,0.0002316686,0.003920249,0.002165967,0.009532776,0.08660253,0.004856377,0.01808149,0.0000931668],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934694,0.0007332487,0.003945474,0.0001661026,0.000008170554,0.00001379597,0.0002148695,0.0000516653,0.001397283],"genre_scores_gemma":[0.994601,0.0007559466,0.003592802,0.0001137994,0.00001473184,0.0000102256,0.0004166354,0.00001790815,0.0004769601],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009130638,"threshold_uncertainty_score":0.00305444,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01080319090292558,"score_gpt":0.224293204564551,"score_spread":0.2134900136616255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}