{"id":"W4393869729","doi":"10.3390/curroncol31040150","title":"KRAS: Biology, Inhibition, and Mechanisms of Inhibitor Resistance","year":2024,"lang":"en","type":"article","venue":"Current Oncology","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Hunter College; Center for the Study of Philanthropy, City University of New York; National Cancer Institute; City University of New York; Damon Runyon Cancer Research Foundation","keywords":"KRAS; Cancer research; Reprogramming; Biology; Mutant; Epigenetics; Mutation; Computational biology; Bioinformatics; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006502065,0.0005466575,0.000455797,0.0008027114,0.0002314998,0.001282194,0.0004655154,0.000703568,0.001103134],"category_scores_gemma":[0.0003722681,0.000258556,0.0003737774,0.0004164691,0.0006601074,0.0009719437,0.00042779,0.001335793,0.000660107],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008833976,"about_ca_system_score_gemma":0.000289331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002523799,"about_ca_topic_score_gemma":0.0003060846,"domain_scores_codex":[0.9996492,0.00006030883,0.00002531759,0.00005599368,0.0001362112,0.00007299582],"domain_scores_gemma":[0.9998246,0.00003590961,0.00006888371,0.00001468582,0.0000319764,0.00002402413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007650468,0.000253402,0.004216756,0.001630994,0.0001043831,0.001156792,0.0003051779,0.002793928,0.5917302,0.03549423,0.006754774,0.3547944],"study_design_scores_gemma":[0.0001404302,0.002341032,0.01435192,0.0003067151,0.0001592504,0.0114898,0.0002556481,0.004345145,0.6082103,0.01401775,0.3442886,0.00009343592],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2433576,0.6670327,0.03080013,0.01533155,0.0007143414,0.0001982737,0.0005017566,0.0009809874,0.04108264],"genre_scores_gemma":[0.7288361,0.2490196,0.005295845,0.001863936,0.0005520789,0.0001406135,0.0003138015,0.00009653749,0.01388137],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001282194,"threshold_uncertainty_score":0.006409526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05783245751205095,"score_gpt":0.3959351655503267,"score_spread":0.3381027080382757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}