{"id":"W4393869729","doi":"10.3390/curroncol31040150","title":"KRAS: Biology, Inhibition, and Mechanisms of Inhibitor Resistance","year":2024,"lang":"en","type":"article","venue":"Current Oncology","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Hunter College; Center for the Study of Philanthropy, City University of New York; National Cancer Institute; City University of New York; Damon Runyon Cancer Research Foundation","keywords":"KRAS; Cancer research; Reprogramming; Biology; Mutant; Epigenetics; Mutation; Computational biology; Bioinformatics; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002120495,0.000106258,0.0003101266,0.0002362357,0.00003453183,0.000008231157,0.00002443026,0.0001163504,0.0002567799],"category_scores_gemma":[0.00006504599,0.00008801305,0.00009681439,0.000276421,0.0002059101,0.00004625402,0.00002858653,0.000196289,0.00003840814],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006659587,"about_ca_system_score_gemma":0.0001446613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002230164,"about_ca_topic_score_gemma":0.00002151862,"domain_scores_codex":[0.9991281,0.00006194464,0.0003037771,0.0002687298,0.00008767317,0.0001497857],"domain_scores_gemma":[0.9995284,0.00008559462,0.00005913472,0.0001236496,0.0001013192,0.0001018865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002210282,0.0008163591,0.001054957,0.00197592,0.0002273654,0.0001666943,0.0006066625,3.268244e-7,0.3521837,0.520142,0.05314425,0.06946076],"study_design_scores_gemma":[0.003319168,0.00130078,0.001167548,0.005275979,0.0005871454,0.0002141079,0.0005665398,0.0005357296,0.122764,0.1899483,0.6738843,0.0004364156],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8666406,0.02857524,0.05943155,0.02428313,0.001799545,0.0008277183,0.0003247995,0.0005262354,0.01759115],"genre_scores_gemma":[0.997781,0.0004454625,0.0007302948,0.0002055442,0.0002303091,0.00002316867,0.0000963322,0.00001122346,0.0004766222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6207401,"threshold_uncertainty_score":0.3589068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05783245751205095,"score_gpt":0.3959351655503267,"score_spread":0.3381027080382757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}