{"id":"W4393899162","doi":"10.1016/j.medj.2024.03.010","title":"TL1A inhibition for inflammatory bowel disease treatment: From inflammation to fibrosis","year":2024,"lang":"en","type":"article","venue":"Med","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; Western University","funders":"","keywords":"Ulcerative colitis; Inflammatory bowel disease; Medicine; Disease; Fibrosis; Immune system; Crohn's disease; Clinical trial; Colitis; Inflammation; Drug development; Immunology; Extracellular matrix; Drug; Internal medicine; Pharmacology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008429043,0.0001927934,0.00009203694,0.00007778443,0.00008210372,0.00008483576,0.00007617826,0.0001003358,0.0000542884],"category_scores_gemma":[0.0001037984,0.0001846054,0.0001589507,0.0000549244,0.00002756553,0.00001386326,0.00004356632,0.00003061086,0.0001610889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007836682,"about_ca_system_score_gemma":0.0001603846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009046491,"about_ca_topic_score_gemma":0.00005820232,"domain_scores_codex":[0.998971,0.00004260478,0.0002202617,0.000420009,0.0001236001,0.0002225436],"domain_scores_gemma":[0.9992869,0.00002218586,0.00003388703,0.0003379195,0.00006170698,0.0002573839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001966963,0.00007462901,0.005354865,0.0002989449,0.0002137072,0.0001723482,0.0004996141,0.0005138266,0.9635835,0.0007014279,0.01326845,0.01335168],"study_design_scores_gemma":[0.002265461,0.0003687597,0.1691839,0.0002640139,0.0003075495,0.000001815567,0.00008102664,0.00292067,0.4898323,0.001864366,0.3320604,0.0008497307],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950705,0.00040332,0.002029903,0.0005239059,0.0003250434,0.0008150573,0.0005680418,0.00009540947,0.0001688239],"genre_scores_gemma":[0.9940775,0.00003314169,0.0004981517,0.00017885,0.001114346,0.0007475217,0.002176396,0.00005167216,0.001122432],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4737513,"threshold_uncertainty_score":0.7527989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007690237893534325,"score_gpt":0.2413867633471387,"score_spread":0.2336965254536044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}