{"id":"W4393926505","doi":"10.1021/acs.biomac.4c00010","title":"Direct Assembly of Bioactive Nanoparticles Constructed from Polyphenol-Nanoengineered Albumin","year":2024,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"Protein Interaction Studies and Fluorescence Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Young Scientists Fund; National Key Research and Development Program of China; Natural Science Foundation of Sichuan Province; State Key Laboratory of Polymer Materials Engineering; Sichuan University; National Natural Science Foundation of China; Department of Science and Technology of Sichuan Province; China Postdoctoral Science Foundation","keywords":"Ibuprofen; Nanocarriers; Nanoparticle; Chemistry; Drug; Immunogenicity; Albumin; Combinatorial chemistry; Nanotechnology; Human serum albumin; Drug delivery; In vivo; Nanomedicine; Serum albumin; Pharmacology; Biochemistry; Materials science; Organic chemistry; Medicine; Antigen; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006131348,0.0001783151,0.0002179602,0.00009076892,0.00005472037,0.00004724394,0.000151068,0.00009972382,0.00005842325],"category_scores_gemma":[0.00006553501,0.0001558721,0.0001889583,0.0002656616,0.0001587774,0.000008107064,0.00009986575,0.00004677362,0.00002903345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001461085,"about_ca_system_score_gemma":0.00005399386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004651321,"about_ca_topic_score_gemma":0.00004719822,"domain_scores_codex":[0.9989472,0.00004628862,0.0002663817,0.0003912127,0.0001424931,0.0002064495],"domain_scores_gemma":[0.9994783,0.00003366613,0.00006582668,0.0002677719,0.00009358586,0.00006081164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005793616,0.0000382437,0.000413588,0.00001699803,0.0006502367,0.00001738396,0.00005895517,0.000002417464,0.9937068,0.0001114212,0.001464834,0.003461206],"study_design_scores_gemma":[0.000163826,0.0001033438,0.001245752,0.0000603651,0.00009254401,0.000007923843,0.0002991455,0.0001735832,0.9928435,0.00003385695,0.004795966,0.0001801763],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988649,0.007779357,0.001905237,0.000128849,0.0002506587,0.0001085452,0.0002875492,0.00004669917,0.000844122],"genre_scores_gemma":[0.9982817,0.0002152175,0.001058605,0.00003345075,0.0001193893,0.0000219204,0.0001177678,0.0000227213,0.0001292315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009632713,"threshold_uncertainty_score":0.635628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007406007190535153,"score_gpt":0.2478383419872308,"score_spread":0.2404323347966957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}