{"id":"W4393926505","doi":"10.1021/acs.biomac.4c00010","title":"Direct Assembly of Bioactive Nanoparticles Constructed from Polyphenol-Nanoengineered Albumin","year":2024,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"Protein Interaction Studies and Fluorescence Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Young Scientists Fund; National Key Research and Development Program of China; Natural Science Foundation of Sichuan Province; State Key Laboratory of Polymer Materials Engineering; Sichuan University; National Natural Science Foundation of China; Department of Science and Technology of Sichuan Province; China Postdoctoral Science Foundation","keywords":"Ibuprofen; Nanocarriers; Nanoparticle; Chemistry; Drug; Immunogenicity; Albumin; Combinatorial chemistry; Nanotechnology; Human serum albumin; Drug delivery; In vivo; Nanomedicine; Serum albumin; Pharmacology; Biochemistry; Materials science; Organic chemistry; Medicine; Antigen; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001208448,0.0003104628,0.0001457094,0.0001563361,0.00008496622,0.0002059259,0.0001415052,0.0002108979,0.0002921272],"category_scores_gemma":[0.0001164995,0.0001255995,0.0001804255,0.0001042479,0.0001291107,0.0001912698,0.0001793386,0.0001775051,0.0001691322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001872298,"about_ca_system_score_gemma":0.0001116462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002813133,"about_ca_topic_score_gemma":0.0004678011,"domain_scores_codex":[0.9999222,0.000008601131,0.000008070958,0.00002652219,0.00001557171,0.00001895279],"domain_scores_gemma":[0.9999412,0.000008301555,0.00002440307,0.000005386111,0.00001027936,0.00001035097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001352318,0.000007665632,0.00004024894,0.0000148192,0.000002317479,0.00001383183,0.000007186404,0.0000661432,0.9989414,0.00004350803,0.000007750869,0.0008416714],"study_design_scores_gemma":[0.00000262671,0.00006737359,0.0003045779,0.000001321846,0.00000509315,0.00002757246,0.000003163211,0.000535241,0.998434,0.000009434073,0.0006077265,0.000001834323],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9787742,0.0008256919,0.01889595,0.00004271407,0.00003069738,0.00006535492,0.00007449416,0.0001483535,0.001142469],"genre_scores_gemma":[0.9847227,0.0004473685,0.01269969,0.00004858625,0.000008615904,0.00003938103,0.0001218382,0.00003568851,0.001876372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003104628,"threshold_uncertainty_score":0.001358449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007406007190535153,"score_gpt":0.2478383419872308,"score_spread":0.2404323347966957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}