{"id":"W4393928612","doi":"10.1002/cbic.202400085","title":"<i>In‐vitro</i> Clinical Diagnostics using RNA‐Cleaving DNAzymes","year":2024,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph’s Healthcare Hamilton; St Joseph's Health Care; McMaster University","funders":"Canadian Institutes of Health Research; Grand Challenges Canada; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Biology; Computational biology; Deoxyribozyme; Nanotechnology; Biochemistry; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003502704,0.0002070295,0.0002381337,0.00007373242,0.000048353,0.00005958517,0.0001691843,0.0002919112,0.000003052118],"category_scores_gemma":[0.0002463871,0.0001919437,0.0002282771,0.0002459757,0.0001433214,0.000007708948,0.0001466542,0.0002305789,0.000008819922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003314197,"about_ca_system_score_gemma":0.00007499068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000999147,"about_ca_topic_score_gemma":0.000003663337,"domain_scores_codex":[0.9985646,0.00004112012,0.0003865592,0.0005720976,0.0001274078,0.000308214],"domain_scores_gemma":[0.9993819,0.00005304334,0.00005594423,0.0003686472,0.00005281867,0.00008761761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002870745,0.00005797687,0.0002125659,0.00003066332,0.00004726158,0.00005004678,0.000009380773,0.000001413779,0.9870481,0.00003061846,0.006186133,0.006297067],"study_design_scores_gemma":[0.0001367226,0.00004531012,0.00004063195,0.00007174996,0.00004340387,0.0000283671,0.00002980098,0.0004488862,0.9651304,0.000133512,0.03363845,0.000252685],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895082,0.007255823,0.001351074,0.0002952036,0.0003624051,0.0001057873,0.00001902344,0.00009875435,0.001003756],"genre_scores_gemma":[0.9889569,0.002773331,0.006181789,0.0005474319,0.0008087792,0.00000474863,0.0000746233,0.00003948212,0.0006128892],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02745232,"threshold_uncertainty_score":0.7827235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02328760747166305,"score_gpt":0.3516920589612993,"score_spread":0.3284044514896363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}