{"id":"W4393928612","doi":"10.1002/cbic.202400085","title":"<i>In‐vitro</i> Clinical Diagnostics using RNA‐Cleaving DNAzymes","year":2024,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph’s Healthcare Hamilton; St Joseph's Health Care; McMaster University","funders":"Canadian Institutes of Health Research; Grand Challenges Canada; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Biology; Computational biology; Deoxyribozyme; Nanotechnology; Biochemistry; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009437455,0.0007234605,0.0004984763,0.0007240922,0.0001859007,0.001050122,0.000651759,0.001331028,0.004870275],"category_scores_gemma":[0.00130872,0.0002669715,0.0004804696,0.0006825504,0.0006017662,0.0007111409,0.0003944084,0.001253084,0.005188519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005276836,"about_ca_system_score_gemma":0.0003780269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005497013,"about_ca_topic_score_gemma":0.0007083373,"domain_scores_codex":[0.9990187,0.0003159096,0.00009435642,0.0001589078,0.0003462403,0.00006595582],"domain_scores_gemma":[0.9993569,0.0002645685,0.0001319058,0.00004733321,0.0001694642,0.00002986778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003555939,0.000132499,0.00171275,0.007073272,0.0001256953,0.0008291106,0.0001808955,0.001013559,0.6684185,0.01700513,0.07135557,0.2317974],"study_design_scores_gemma":[0.00002196469,0.0005656104,0.001219104,0.0004362919,0.00006583348,0.002458608,0.00005068901,0.001007334,0.5219015,0.001801152,0.4704147,0.00005724383],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.02628308,0.6557439,0.1813076,0.01149496,0.009444575,0.0004912341,0.003548897,0.002388809,0.109297],"genre_scores_gemma":[0.2395109,0.5419635,0.1242426,0.01506288,0.007099322,0.0009156791,0.006530578,0.0004944045,0.06418012],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.004870275,"threshold_uncertainty_score":0.01629269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02328760747166305,"score_gpt":0.3516920589612993,"score_spread":0.3284044514896363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}