{"id":"W4393931424","doi":"10.1001/jamaoncol.2024.0194","title":"Clinical Value of Molecular Targets and FDA-Approved Genome-Targeted Cancer Therapies","year":2024,"lang":"en","type":"article","venue":"JAMA Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Medicine; Clinical trial; Personalized medicine; Targeted therapy; Cancer drugs; Oncology; Cancer; Internal medicine; Bioinformatics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04136049,0.0003599535,0.001030499,0.003512884,0.0003298988,0.00189898,0.0007249269,0.0008027481,0.006252194],"category_scores_gemma":[0.1168194,0.0001757885,0.00235439,0.00478537,0.001122036,0.002524532,0.0013456,0.001109283,0.0005286378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001088479,"about_ca_system_score_gemma":0.00162521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007085523,"about_ca_topic_score_gemma":0.001276948,"domain_scores_codex":[0.962923,0.01645764,0.008231259,0.003296715,0.008420233,0.0006709843],"domain_scores_gemma":[0.792479,0.0985728,0.09370025,0.005954982,0.00748615,0.001806766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.006978203,0.0001259863,0.893769,0.003787841,0.00481687,0.0001776763,0.000214643,0.001729165,0.0004756135,0.002199406,0.002675017,0.0830505],"study_design_scores_gemma":[0.000893773,0.002855448,0.9578313,0.003160842,0.005678511,0.001150645,0.0004009823,0.002720979,0.0007962148,0.005127038,0.01930648,0.00007763843],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.7379758,0.1892732,0.008193817,0.009072664,0.0005257086,0.001247721,0.02813549,0.00006544303,0.0255101],"genre_scores_gemma":[0.9881822,0.004688865,0.001888821,0.0008295548,0.0003727046,0.0002569613,0.00337137,0.00001224314,0.0003972136],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.04136049,"threshold_uncertainty_score":0.2187378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01253038367930686,"score_gpt":0.3239719103137947,"score_spread":0.3114415266344879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}