{"id":"W4393931424","doi":"10.1001/jamaoncol.2024.0194","title":"Clinical Value of Molecular Targets and FDA-Approved Genome-Targeted Cancer Therapies","year":2024,"lang":"en","type":"article","venue":"JAMA Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Medicine; Clinical trial; Personalized medicine; Targeted therapy; Cancer drugs; Oncology; Cancer; Internal medicine; Bioinformatics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000325949,0.000144665,0.0002851404,0.00004730526,0.00002945238,0.00002589411,0.0001417369,0.0003337761,0.00004753089],"category_scores_gemma":[0.0001477988,0.0001329875,0.000127343,0.00007533901,0.0002114568,0.000003235932,0.0001542739,0.0001594769,0.000004104285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003282694,"about_ca_system_score_gemma":0.0003435298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009062474,"about_ca_topic_score_gemma":0.0001010482,"domain_scores_codex":[0.9988592,0.0001048814,0.0003450876,0.0004029129,0.00007197769,0.0002159415],"domain_scores_gemma":[0.9994124,0.00008922643,0.00008389428,0.0002362427,0.00008573676,0.00009248596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002157181,0.000130282,0.004402112,0.00009503223,0.0004808025,0.00005224219,0.0002343569,0.0001613282,0.9006566,0.003787759,0.005101012,0.08468269],"study_design_scores_gemma":[0.001439849,0.001751403,0.02260548,0.00002875924,0.0001485073,0.0000282463,0.0001269253,0.0008569857,0.08601157,0.002365519,0.8842749,0.0003618737],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9239164,0.07030734,0.001543371,0.001927724,0.0007164857,0.0001992031,0.0001214073,0.00001489886,0.001253147],"genre_scores_gemma":[0.9834678,0.01214814,0.001922308,0.00160638,0.000518854,0.00004528291,0.00007320297,0.00003171389,0.000186274],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8791739,"threshold_uncertainty_score":0.5423071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01253038367930686,"score_gpt":0.3239719103137947,"score_spread":0.3114415266344879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}