{"id":"W4393932111","doi":"10.3390/cells13070628","title":"Generation of Artificial Blastoids Combining miR-200-Mediated Reprogramming and Mechanical Cues","year":2024,"lang":"en","type":"article","venue":"Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Carraresi Foundation; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Reprogramming; Cell biology; Blastocyst; Inner cell mass; Biology; Regenerative medicine; Somatic cell; Embryonic stem cell; Cell; Chemistry; Embryo; Stem cell; Embryogenesis; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002595022,0.0004803689,0.0003200495,0.0002815239,0.0001857121,0.0003961135,0.0002274572,0.0003932896,0.0009536839],"category_scores_gemma":[0.000188241,0.0001986615,0.0002509388,0.0001744616,0.0002097985,0.0002218517,0.0003480139,0.0004376436,0.0008890667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001737713,"about_ca_system_score_gemma":0.0002239619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000216505,"about_ca_topic_score_gemma":0.0005425758,"domain_scores_codex":[0.9998013,0.00002439267,0.00002739356,0.00004391418,0.00008493881,0.00001793773],"domain_scores_gemma":[0.999905,0.0000201081,0.0000269168,0.00001839368,0.00001358671,0.00001597385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001160823,0.000005869915,0.00007408194,0.00002944079,0.000002692073,0.00007835148,0.00001086398,0.00007468605,0.9978938,0.0001475335,0.00003291306,0.001638139],"study_design_scores_gemma":[0.000005508068,0.00006757407,0.0006700171,0.000006168272,0.00001044721,0.0003443429,0.00001083189,0.0008181799,0.991348,0.00005888201,0.006654268,0.000005830793],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7597806,0.004038017,0.2124875,0.0002621172,0.0004627775,0.0008383166,0.002131236,0.001550954,0.01844854],"genre_scores_gemma":[0.8722398,0.003295711,0.1087088,0.0001891091,0.00005186008,0.0004763448,0.002290323,0.0001969751,0.01255111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009536839,"threshold_uncertainty_score":0.003190339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03462121518121841,"score_gpt":0.292269870179427,"score_spread":0.2576486549982085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}