{"id":"W4393932744","doi":"10.1093/molbev/msae066","title":"Inter-species Transcriptomic Analysis Reveals a Constitutive Adaptation Against Oxidative Stress for the Highly Virulent <i>Leptospira</i> Species","year":2024,"lang":"en","type":"article","venue":"Molecular Biology and Evolution","topic":"Leptospirosis research and findings","field":"Immunology and Microbiology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Fonds de Recherche du Québec - Santé; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Institut Pasteur","keywords":"Biology; Transcriptome; Virulence; Adaptation (eye); Leptospira; Oxidative stress; Genetics; Gene; Evolutionary biology; Computational biology; Microbiology; Gene expression; Serotype; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002067656,0.0003028767,0.0002694619,0.0005144844,0.000343598,0.00048596,0.0002064807,0.0003936386,0.001075386],"category_scores_gemma":[0.0003986795,0.0002500189,0.0004077023,0.0004894914,0.0002567774,0.0003859907,0.0005073076,0.0004739399,0.0004770986],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001854141,"about_ca_system_score_gemma":0.0001597923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005368658,"about_ca_topic_score_gemma":0.0009411891,"domain_scores_codex":[0.9997746,0.00001466387,0.00001329357,0.0001214043,0.00004042236,0.0000355188],"domain_scores_gemma":[0.9997165,0.00007282036,0.00009057319,0.00003508885,0.00004517015,0.00003982684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00008859915,0.00001122912,0.005668691,0.00007906595,0.00001045658,0.00007345738,0.0001404018,0.00005781489,0.9901888,0.00005424776,0.00006416605,0.003562935],"study_design_scores_gemma":[0.00001671005,0.0005773324,0.6855336,0.00006070328,0.0001359998,0.001538597,0.000857406,0.003916795,0.297599,0.000798483,0.008909446,0.00005588745],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859783,0.000445843,0.007970349,0.0001036355,0.00001782612,0.00003655875,0.003656742,0.0003480148,0.00144269],"genre_scores_gemma":[0.976971,0.0003811835,0.0148002,0.0001579248,0.0000195653,0.00008485326,0.006114156,0.0002086058,0.001262493],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001075386,"threshold_uncertainty_score":0.003597558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01608246637270426,"score_gpt":0.2660527782564584,"score_spread":0.2499703118837542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}