{"id":"W4393940733","doi":"10.1002/cpz1.1009","title":"Advancing Genetic Alphabet Expansion: Synthesis of 7‐(2‐Thienyl)‐Imidazo[4,5‐b]pyridine (Ds) and 4‐(4‐Pentyne‐1,2‐diol)‐1‐Propynyl‐2‐Nitropyrrole (Diol‐Px) for Use in Replicable Unnatural Base Pairs for PCR Applications","year":2024,"lang":"en","type":"article","venue":"Current Protocols","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"","keywords":"Deoxyribonucleoside; Deoxyribonucleosides; Chemistry; DNA; Combinatorial chemistry; Phosphoramidite; Oligonucleotide; Stereochemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004592307,0.0003162531,0.0004302875,0.0001589079,0.000124215,0.0000789757,0.0002176114,0.0001860609,0.000002113211],"category_scores_gemma":[0.0003585645,0.0002715808,0.0002352969,0.0003199641,0.0001423737,0.00003097308,0.0001275319,0.0001518438,6.489394e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004529965,"about_ca_system_score_gemma":0.0001067962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000832957,"about_ca_topic_score_gemma":0.00002618982,"domain_scores_codex":[0.9978454,0.00006844335,0.0006003416,0.0009012283,0.0001556803,0.0004289203],"domain_scores_gemma":[0.9986473,0.0001762436,0.0001819725,0.0006472609,0.0002315207,0.000115654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000479193,0.000291269,0.001213508,0.001738534,0.00008891692,0.00000226944,0.0000211812,0.0001601774,0.8069423,0.0001572335,0.002207208,0.1866982],"study_design_scores_gemma":[0.0006164954,0.0004228188,0.0001810834,0.0007474791,0.00009287952,0.000009982069,0.00004056068,0.008632693,0.8683653,0.0005497601,0.1199526,0.0003883193],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.601626,0.00800027,0.2219103,0.0006113736,0.000229887,0.1659665,0.001222185,0.0003873944,0.00004604397],"genre_scores_gemma":[0.7944927,0.0003619934,0.04605171,0.00005364608,0.0003055829,0.1583212,0.0002780782,0.00007428329,0.00006080388],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1928667,"threshold_uncertainty_score":0.9999737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02705874564142028,"score_gpt":0.344204158210123,"score_spread":0.3171454125687027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}