{"id":"W4393944359","doi":"10.1101/2024.04.03.24305263","title":"Investigating the relationship between DNA methylation, genetic variation, and suicide attempt in bipolar disorder","year":2024,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Center for Advancing Translational Sciences; National Institute of Mental Health; National Institutes of Health; Roy J. Carver Charitable Trust","keywords":"Variation (astronomy); DNA methylation; Bipolar disorder; Suicide attempt; Genetic variation; Psychology; Genetics; Biology; Psychiatry; Medicine; Medical emergency; Suicide prevention; Gene; Poison control; Cognition; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002847377,0.0001172355,0.000162785,0.0004632414,0.0001971343,0.0002191727,0.00008554197,0.0001941643,0.001542787],"category_scores_gemma":[0.0005541547,0.0001011789,0.0001707918,0.0004112974,0.00009543584,0.00006406245,0.000134721,0.0002008777,0.0001271766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001751393,"about_ca_system_score_gemma":0.0001076273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00224977,"about_ca_topic_score_gemma":0.004194214,"domain_scores_codex":[0.9998838,0.00003676248,0.00001257217,0.00002687565,0.00002275076,0.00001728929],"domain_scores_gemma":[0.9997757,0.00006094022,0.00009504499,0.0000101964,0.00002210188,0.00003613151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007147093,0.00009054775,0.9584459,0.0001012085,0.0002696413,0.0002183986,0.000212767,0.0001407784,0.01831919,0.00006600739,0.0004844027,0.02093653],"study_design_scores_gemma":[0.0000218907,0.0002570077,0.996768,0.00002731188,0.0001076854,0.0003299417,0.0001281589,0.0002206884,0.001486559,0.00008331358,0.0005657424,0.000003742728],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975508,0.001100669,0.0002329665,0.0001112045,0.000007943324,0.00001277917,0.0004865521,0.00000736745,0.0004897279],"genre_scores_gemma":[0.9983404,0.0004893157,0.0004643052,0.00008571361,0.000008988078,0.00001094232,0.0003330029,0.000002122213,0.0002652858],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00224977,"threshold_uncertainty_score":0.005161107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05034931702188759,"score_gpt":0.3098606794512672,"score_spread":0.2595113624293796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}