{"id":"W4393950215","doi":"10.1016/j.ccell.2024.03.008","title":"Mutant IDH inhibitors induce lineage differentiation in IDH-mutant oligodendroglioma","year":2024,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University Health Network; Princess Margaret Cancer Centre; Montreal Neurological Institute and Hospital","funders":"Division of Chemistry; National Cancer Institute; National Institutes of Health; Servier; Massachusetts General Hospital; Engineering Research Centers; Sanofi; European Commission; Broad Institute; Dana-Farber Cancer Institute; Human Frontier Science Program; Council for Higher Education; Novocure; Agios Pharmaceuticals; Eli Lilly and Company","keywords":"Oligodendroglioma; Mutant; Biology; Lineage (genetic); Transcriptome; IDH1; Glioma; Cellular differentiation; Cancer research; Cell; Genetics; Cell biology; Gene; Gene expression; Astrocytoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008721981,0.0002083493,0.0002831427,0.0001968314,0.00003732831,0.00005372581,0.00005940402,0.0001249307,0.000466074],"category_scores_gemma":[0.00001113205,0.0001642821,0.0001179336,0.0004324462,0.00002564441,0.000103313,0.00004174893,0.000199798,0.0001150558],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005797934,"about_ca_system_score_gemma":0.0001448776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006756951,"about_ca_topic_score_gemma":0.0004583987,"domain_scores_codex":[0.9986764,0.00002573881,0.0003169451,0.0003981975,0.0002557049,0.000327017],"domain_scores_gemma":[0.9994974,0.00004954831,0.00004853895,0.0002275345,0.00003771595,0.0001392289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001559542,0.00174728,0.07949723,0.001137991,0.0002933767,0.005197254,0.002946823,0.0001211234,0.8778264,0.0007827308,0.003566802,0.02672707],"study_design_scores_gemma":[0.001921515,0.0001770163,0.02452534,0.0008345437,0.0002142482,0.00003824098,0.0001801109,0.00210688,0.9634995,0.00005410391,0.006229253,0.0002191994],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982822,0.01275885,0.00002199735,0.0007639613,0.001134387,0.0004402223,0.00003818628,0.00009964246,0.001920741],"genre_scores_gemma":[0.9973969,0.001443441,0.00004631942,0.0001712197,0.0004534168,0.0002032674,0.00004416001,0.00004250377,0.0001987615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08567318,"threshold_uncertainty_score":0.6699229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01550369579532616,"score_gpt":0.2783538221535272,"score_spread":0.262850126358201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}