{"id":"W4393950215","doi":"10.1016/j.ccell.2024.03.008","title":"Mutant IDH inhibitors induce lineage differentiation in IDH-mutant oligodendroglioma","year":2024,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University Health Network; Princess Margaret Cancer Centre; Montreal Neurological Institute and Hospital","funders":"Division of Chemistry; National Cancer Institute; National Institutes of Health; Servier; Massachusetts General Hospital; Engineering Research Centers; Sanofi; European Commission; Broad Institute; Dana-Farber Cancer Institute; Human Frontier Science Program; Council for Higher Education; Novocure; Agios Pharmaceuticals; Eli Lilly and Company","keywords":"Oligodendroglioma; Mutant; Biology; Lineage (genetic); Transcriptome; IDH1; Glioma; Cellular differentiation; Cancer research; Cell; Genetics; Cell biology; Gene; Gene expression; Astrocytoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005357991,0.0001038923,0.0001825902,0.0001456026,0.00009892824,0.000227281,0.00006076117,0.0001168798,0.0005116094],"category_scores_gemma":[0.0001258291,0.00006516623,0.00008988404,0.00007612041,0.0000885385,0.0000701051,0.00009274859,0.0002246454,0.0001222312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001791072,"about_ca_system_score_gemma":0.0001141688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005687065,"about_ca_topic_score_gemma":0.001443443,"domain_scores_codex":[0.9999563,0.000004739104,0.00000427797,0.00001072722,0.0000124826,0.00001142134],"domain_scores_gemma":[0.9999493,0.000009356543,0.00001175755,0.00000624787,0.000006659265,0.00001654619],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003729435,0.00003090102,0.008102853,0.00002302162,0.00001434752,0.0002205749,0.00005897627,0.0002112509,0.98405,0.00005920439,0.00009758649,0.006758456],"study_design_scores_gemma":[0.0000500658,0.001504666,0.2010266,0.000009265554,0.00006818163,0.002537661,0.0002714764,0.002043139,0.7878562,0.0001681588,0.004453412,0.00001111404],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990395,0.0002083806,0.0002373883,0.0000158412,0.000002757649,0.000007502762,0.0001240669,0.0000144784,0.0003501853],"genre_scores_gemma":[0.9988775,0.0001165089,0.0003650114,0.00002743729,0.000001435356,0.000009044984,0.000230134,0.000006397433,0.0003664865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005687065,"threshold_uncertainty_score":0.001711547,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01550369579532616,"score_gpt":0.2783538221535272,"score_spread":0.262850126358201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}