{"id":"W4393952355","doi":"10.1016/j.eururo.2024.03.023","title":"Infigratinib Versus Placebo for Patients with High-risk Resected Urothelial Cancer Bearing an FGFR3 Genomic Alteration: Results from the PROOF302 Phase 3 Trial","year":2024,"lang":"en","type":"letter","venue":"European Urology","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Urothelial cancer; Placebo; Oncology; Cancer; Internal medicine; Urothelial carcinoma; Bladder cancer; Urology; Surgery; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001429487,0.0007150876,0.001969579,0.0001856667,0.0003958564,0.0009966979,0.0005344488,0.002682951,0.005220604],"category_scores_gemma":[0.003557827,0.000267921,0.001723504,0.0002815677,0.0005013773,0.001005481,0.0002605434,0.003836703,0.001125381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001382451,"about_ca_system_score_gemma":0.0007870679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008847834,"about_ca_topic_score_gemma":0.003811791,"domain_scores_codex":[0.9994217,0.00031311,0.00004572954,0.00007469996,0.00005901578,0.00008580948],"domain_scores_gemma":[0.9988735,0.0005894356,0.0001995883,0.00004336432,0.00008138071,0.000212795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5973037,0.001939993,0.004330785,0.003528743,0.003462732,0.00134341,0.0002465328,0.002010532,0.006107689,0.001719987,0.1028739,0.275132],"study_design_scores_gemma":[0.8728316,0.04356928,0.01200744,0.0006545144,0.002330867,0.001451838,0.0002546858,0.002941964,0.001861337,0.006448195,0.05553472,0.0001136122],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6717367,0.09033316,0.001868172,0.171219,0.01714738,0.001919423,0.006926056,0.0005566219,0.03829351],"genre_scores_gemma":[0.9138567,0.01137336,0.001646261,0.05012175,0.003746824,0.0009036497,0.002260907,0.00007525543,0.0160153],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005220604,"threshold_uncertainty_score":0.01746464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03506205683462299,"score_gpt":0.3012544102331573,"score_spread":0.2661923533985343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}