{"id":"W4393953369","doi":"10.1016/j.jbc.2024.107207","title":"Tryptophan residues in TDP-43 and SOD1 modulate the cross-seeding and toxicity of SOD1","year":2024,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; University of Alberta; University of British Columbia","funders":"Canadian Institutes of Health Research; ALS Society of Canada; Alberta Innovates; R. Howard Webster Foundation; Fondation Brain Canada; Amorfix Life Sciences","keywords":"SOD1; Chemistry; Tryptophan; Cell biology; Amyotrophic lateral sclerosis; Zebrafish; Mutant; Biochemistry; Molecular biology; Biology; Gene; Amino acid; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009410165,0.0001950285,0.0001719987,0.0000573889,0.00008848313,0.0001653512,0.0001347262,0.0002229463,0.0007640491],"category_scores_gemma":[0.00008934678,0.00008985182,0.0001356956,0.00004229446,0.000125125,0.0001343786,0.0001700588,0.0002587188,0.0001850884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001603628,"about_ca_system_score_gemma":0.0001038633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003053565,"about_ca_topic_score_gemma":0.0003316332,"domain_scores_codex":[0.9999357,0.00001170278,0.000006076085,0.00001519398,0.00001356316,0.00001774019],"domain_scores_gemma":[0.9999483,0.000005825627,0.00001674366,0.000003972702,0.000005340759,0.00001992342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001233811,0.00002015393,0.0001159121,0.00001557084,0.000003200078,0.00002783626,0.000005772767,0.00003128589,0.999062,0.00004305521,0.00001097156,0.0005408484],"study_design_scores_gemma":[0.00002959126,0.0006242431,0.007845103,0.000006115336,0.0000241184,0.0002837183,0.0000265032,0.001192623,0.9886215,0.00006859229,0.001272633,0.000005194128],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982777,0.0007157214,0.0005583653,0.00002818503,0.000007620828,0.000008964401,0.00003032872,0.00001932739,0.0003537612],"genre_scores_gemma":[0.9984422,0.0003367005,0.0004108913,0.00002453653,0.000002934534,0.0000129886,0.00004725824,0.000005161482,0.0007174106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007640491,"threshold_uncertainty_score":0.002555966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05125551874816015,"score_gpt":0.3443577728611252,"score_spread":0.293102254112965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}