{"id":"W4393971224","doi":"10.14356/kona.2025008","title":"Strategies to Overcome Undesired Physicochemical Changes in Particle Engineering for Inhalation","year":2024,"lang":"en","type":"article","venue":"KONA Powder and Particle Journal","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Materials science; Particle (ecology); Crystallization; Amorphous solid; Spray drying; Chemical engineering; Triboelectric effect; Particle size; Dry-powder inhaler; Nanotechnology; Process engineering; Composite material; Inhaler; Organic chemistry; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000644428,0.0006218766,0.0005256352,0.000677079,0.0003550581,0.0008788095,0.0005470914,0.0007790672,0.002123083],"category_scores_gemma":[0.0005629347,0.000339225,0.0008306163,0.0004112923,0.0005075301,0.001284806,0.0007543227,0.001824068,0.001078188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003800098,"about_ca_system_score_gemma":0.0005300188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003041249,"about_ca_topic_score_gemma":0.000720959,"domain_scores_codex":[0.9995915,0.00006102553,0.00003293223,0.00008013174,0.0001675278,0.00006687657],"domain_scores_gemma":[0.9997413,0.00007053577,0.0000797889,0.00003023903,0.00005956028,0.00001862988],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000855988,0.0002568088,0.0003846651,0.003590544,0.00009498093,0.0004800683,0.0002570862,0.001730308,0.8694075,0.01289707,0.001878121,0.1089373],"study_design_scores_gemma":[0.00005037482,0.001500398,0.001506968,0.0004401905,0.0001741944,0.001542083,0.0002052056,0.005254965,0.7823457,0.005636486,0.2012792,0.00006416548],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.202144,0.3032147,0.4403101,0.004137135,0.001883245,0.001365667,0.0003691066,0.001321745,0.04525428],"genre_scores_gemma":[0.6210402,0.17521,0.1816859,0.002289383,0.0004948241,0.0009069163,0.0004111577,0.0002784695,0.01768316],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002123083,"threshold_uncertainty_score":0.00710243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02954152342298243,"score_gpt":0.3035976857906366,"score_spread":0.2740561623676542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}