{"id":"W4393983153","doi":"10.1158/1538-7445.am2024-ct081","title":"Abstract CT081: A phase 1/2 study investigating the safety and efficacy of autologous TAC T cells in subjects with unresectable, locally advanced, or metastatic claudin 18.2+ solid tumors","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Phase (matter); Oncology; Internal medicine; Claudin; Phases of clinical research; Cancer research; Toxicity; Chemistry; Tight junction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001579409,0.001875064,0.001676365,0.000506237,0.0006471654,0.0008899418,0.001094981,0.001787829,0.006486299],"category_scores_gemma":[0.0009057585,0.0005979554,0.0009248754,0.0004338211,0.001114523,0.0007764454,0.0002930866,0.003971427,0.001995167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001176724,"about_ca_system_score_gemma":0.002580848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001518,"about_ca_topic_score_gemma":0.003121753,"domain_scores_codex":[0.9995228,0.000215475,0.00002279915,0.00008551164,0.00005267104,0.0001008542],"domain_scores_gemma":[0.999033,0.0001363915,0.0001590045,0.00008014082,0.0000979436,0.0004936728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5607215,0.1583912,0.009626304,0.001262554,0.00104622,0.0008755346,0.000501634,0.002662756,0.1791782,0.000495424,0.01466996,0.07056869],"study_design_scores_gemma":[0.2251049,0.7542118,0.007587499,0.0000340852,0.0002852321,0.00046795,0.00005766495,0.0007876758,0.008015675,0.0001448611,0.003277537,0.00002499062],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844023,0.001101294,0.0009665684,0.0005952612,0.0001397288,0.006328693,0.003384159,0.0002383106,0.002843589],"genre_scores_gemma":[0.9733093,0.001042558,0.002776189,0.001365474,0.0002233151,0.008118269,0.005561083,0.0000749618,0.007528764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006486299,"threshold_uncertainty_score":0.02169883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09422062859099477,"score_gpt":0.4516854115260862,"score_spread":0.3574647829350914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}