{"id":"W4393983276","doi":"10.1158/1538-7445.am2024-ct063","title":"Abstract CT063: Phase Ib trial of ATR inhibitor (ATRi) tuvusertib + ATM inhibitor (ATMi) lartesertib (M4076) in patients (pts) with advanced solid tumors","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Phase (matter); Internal medicine; Pharmacology; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006616539,0.001191845,0.001313601,0.0003174337,0.0003784524,0.0009459183,0.0006092968,0.0008125606,0.006150444],"category_scores_gemma":[0.0003600312,0.0003670277,0.0008286526,0.0004548157,0.0006181269,0.0005840712,0.0002969084,0.002314584,0.001415506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008210079,"about_ca_system_score_gemma":0.001369318,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00133868,"about_ca_topic_score_gemma":0.003816402,"domain_scores_codex":[0.999826,0.00006916179,0.00001201684,0.00003400808,0.00001784026,0.00004091542],"domain_scores_gemma":[0.999808,0.0000240814,0.00003096061,0.00001239271,0.00001152661,0.0001129947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6671163,0.03064565,0.008785799,0.001417884,0.001281017,0.0005433394,0.0002913216,0.004805392,0.1250743,0.0007374525,0.01497157,0.1443298],"study_design_scores_gemma":[0.4363117,0.5139839,0.02089511,0.0001188044,0.0007281086,0.0009416838,0.0001153606,0.002912179,0.01286768,0.0003810189,0.01069639,0.00004804087],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855754,0.003242715,0.000471101,0.0004724228,0.0001157284,0.001744172,0.003092797,0.0002127933,0.005072905],"genre_scores_gemma":[0.9833576,0.002159735,0.001265593,0.0007412616,0.0001425106,0.001596692,0.005545784,0.00003775993,0.005153026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006150444,"threshold_uncertainty_score":0.02057534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04407971436405525,"score_gpt":0.4237694089581737,"score_spread":0.3796896945941184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}