{"id":"W4393983276","doi":"10.1158/1538-7445.am2024-ct063","title":"Abstract CT063: Phase Ib trial of ATR inhibitor (ATRi) tuvusertib + ATM inhibitor (ATMi) lartesertib (M4076) in patients (pts) with advanced solid tumors","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Phase (matter); Internal medicine; Pharmacology; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001982641,0.0004478402,0.0009881112,0.001116604,0.0001446933,0.000129264,0.0005245921,0.0003009381,0.0007673003],"category_scores_gemma":[0.001165485,0.0003504063,0.0002317264,0.002631134,0.0006831008,0.0004948464,0.0003132928,0.001803876,0.0002411334],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.01543544,"about_ca_system_score_gemma":0.01960758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001869512,"about_ca_topic_score_gemma":0.0005797574,"domain_scores_codex":[0.9922787,0.0002602504,0.001153258,0.001178079,0.003436297,0.00169344],"domain_scores_gemma":[0.9962576,0.0008236598,0.0001315429,0.001049455,0.001037644,0.0007000723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5786452,0.01073924,0.006213973,0.0104156,0.001027016,0.005430658,0.004530639,0.0004689795,0.1796919,0.0002009463,0.03728735,0.1653485],"study_design_scores_gemma":[0.6774261,0.01940293,0.002868664,0.01015528,0.0001235413,0.00004384247,0.0007022576,0.002654244,0.2683989,0.0001197614,0.01717818,0.000926295],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910228,0.002383506,0.000004354282,0.0007146574,0.0005634834,0.003886622,0.0001256051,0.0001191609,0.001179791],"genre_scores_gemma":[0.9953589,0.0004429063,0.00007675336,0.00004644178,0.00115928,0.0007661436,0.00009224449,0.0001719884,0.001885338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1644222,"threshold_uncertainty_score":0.9998948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04407971436405525,"score_gpt":0.4237694089581737,"score_spread":0.3796896945941184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}