{"id":"W4393983476","doi":"10.1158/1538-7445.am2024-ct286","title":"Abstract CT286: TILVANCE-301, a phase 3 study of lifileucel tumor-infiltrating lymphocyte (TIL) cell therapy in combination with pembrolizumab vs pembrolizumab alone in treatment-naive unresectable or metastatic melanoma","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Pembrolizumab; Medicine; Tumor-infiltrating lymphocytes; Melanoma; Oncology; Metastatic melanoma; Immunotherapy; Internal medicine; Cancer; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00167148,0.001797727,0.001919209,0.0003494156,0.000772603,0.001251391,0.001288587,0.00226071,0.009298985],"category_scores_gemma":[0.0009424364,0.0007510784,0.001567322,0.0003521916,0.0009876089,0.001024773,0.0003395084,0.005543812,0.002081215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001370434,"about_ca_system_score_gemma":0.002758742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00158661,"about_ca_topic_score_gemma":0.004224838,"domain_scores_codex":[0.9995746,0.0001978967,0.0000254869,0.00007329213,0.00005434208,0.00007432769],"domain_scores_gemma":[0.9990717,0.0001280286,0.0001639821,0.00006423547,0.00006834239,0.0005036222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8456903,0.05019518,0.002892207,0.001010324,0.0009075955,0.0002504428,0.0001443581,0.001306435,0.05075905,0.0003154006,0.009881492,0.03664731],"study_design_scores_gemma":[0.7501282,0.2390094,0.004343645,0.00004305853,0.000294961,0.0001460674,0.00002737873,0.0007122618,0.003119447,0.0001891326,0.001962281,0.00002408949],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9715566,0.002889029,0.000692259,0.001691302,0.0005635921,0.01044185,0.005470316,0.0003005802,0.006394438],"genre_scores_gemma":[0.9646081,0.001840325,0.002426561,0.002763698,0.0004445305,0.008567451,0.007039809,0.00007115999,0.01223845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009298985,"threshold_uncertainty_score":0.0311082,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09603221829209885,"score_gpt":0.4251622067439079,"score_spread":0.3291299884518091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}