{"id":"W4393985505","doi":"10.1158/1538-7445.am2024-ct184","title":"Abstract CT184: First-in-human trial of TIGIT inhibitor M6223 as monotherapy or in combination with bintrafusp alfa (BA) in patients (pts) with advanced solid unresectable tumors","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Solid tumor; TIGIT; Oncology; Internal medicine; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004109945,0.0001799844,0.0002598791,0.000462082,0.00005939763,0.00006546488,0.0002231952,0.0001044051,0.0001176227],"category_scores_gemma":[0.00005817584,0.0001331514,0.00003689163,0.000827799,0.0001707762,0.00003288081,0.00006404975,0.0003646757,0.000006139821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004460729,"about_ca_system_score_gemma":0.0008966763,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005778119,"about_ca_topic_score_gemma":0.03913448,"domain_scores_codex":[0.997798,0.00009819563,0.0003032351,0.0005457352,0.0006520543,0.0006028361],"domain_scores_gemma":[0.9993134,0.0000558714,0.00004859928,0.0002945048,0.0001753166,0.0001123479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.4917774,0.007811432,0.1875409,0.001516223,0.0005207343,0.0009544115,0.001408827,0.003207568,0.2366969,0.0002012363,0.002086691,0.06627753],"study_design_scores_gemma":[0.2007999,0.03435678,0.07305921,0.002943855,0.00001162892,0.000004963683,0.0003551008,0.0001335042,0.6806904,0.0004011601,0.006526505,0.0007169471],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969622,0.0007202314,0.000002187809,0.000175427,0.00004982414,0.001517552,0.00004721077,0.000007775548,0.0005175441],"genre_scores_gemma":[0.9976525,0.0008552717,0.00001558492,0.00001017294,0.00007014777,0.0007173719,0.0001111942,0.00004604655,0.000521659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4439934,"threshold_uncertainty_score":0.9783988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0241756883097609,"score_gpt":0.3785753290395207,"score_spread":0.3543996407297598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}