{"id":"W4393985505","doi":"10.1158/1538-7445.am2024-ct184","title":"Abstract CT184: First-in-human trial of TIGIT inhibitor M6223 as monotherapy or in combination with bintrafusp alfa (BA) in patients (pts) with advanced solid unresectable tumors","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Solid tumor; TIGIT; Oncology; Internal medicine; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006949248,0.001547878,0.001847992,0.0004731533,0.0004871975,0.001057047,0.0007455812,0.00109126,0.00702291],"category_scores_gemma":[0.0006189042,0.000516382,0.0009110763,0.0004566692,0.0006095538,0.0007883233,0.0003023778,0.003175714,0.001217792],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001265813,"about_ca_system_score_gemma":0.001820201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00147956,"about_ca_topic_score_gemma":0.003892162,"domain_scores_codex":[0.9997879,0.00008905314,0.00001107829,0.00003519392,0.00002317419,0.00005374544],"domain_scores_gemma":[0.9996977,0.00003558706,0.00005995717,0.00001693534,0.0000176705,0.0001722443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7844665,0.05191875,0.003199631,0.001196046,0.001145851,0.0003056001,0.000215491,0.002741551,0.0392436,0.0004517496,0.009634059,0.1054812],"study_design_scores_gemma":[0.4739769,0.5074963,0.006016086,0.00004865064,0.0004627233,0.0002632443,0.00004406126,0.001127902,0.005205265,0.0002020425,0.005127537,0.00002927057],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880371,0.003023351,0.0004349274,0.0006372479,0.0002090597,0.002297346,0.001776378,0.0002151953,0.003369408],"genre_scores_gemma":[0.9849902,0.002202804,0.001130047,0.0008481776,0.0003090042,0.001683849,0.002388786,0.00003852438,0.006408517],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00702291,"threshold_uncertainty_score":0.02349401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0241756883097609,"score_gpt":0.3785753290395207,"score_spread":0.3543996407297598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}