{"id":"W4393986770","doi":"10.1111/acel.14150","title":"Progeria‐based vascular model identifies networks associated with cardiovascular aging and disease","year":2024,"lang":"en","type":"article","venue":"Aging Cell","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; University of Alberta; Stem Cell Network; Agricultural Institute of Canada; Ottawa Hospital","funders":"Canadian Institutes of Health Research; Ottawa Hospital; Canada Research Chairs","keywords":"Progeria; Biology; Lamin; Premature aging; Histone; Vascular smooth muscle; Acetylation; SIRT6; Epigenetics; LMNA; Cell biology; Downregulation and upregulation; Genetics; Sirtuin; Endocrinology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001603388,0.0001344366,0.0001104669,0.00003364038,0.00008996546,0.0001167376,0.00005663696,0.00006731551,0.000003423427],"category_scores_gemma":[0.00001462334,0.0001147142,0.0001305863,0.00008420512,0.00004421114,0.000007534803,0.00004142321,0.00009378717,0.000001653653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001123666,"about_ca_system_score_gemma":0.00005596356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008959812,"about_ca_topic_score_gemma":0.000004229256,"domain_scores_codex":[0.9992027,0.00003616079,0.00008113006,0.0003636394,0.0001340467,0.000182315],"domain_scores_gemma":[0.999579,0.000006425922,0.00001872866,0.0002670118,0.0000339197,0.00009493348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001979872,0.0001436852,0.01302967,0.001048134,0.003731702,0.0003677321,0.0004730158,0.8059968,0.1484043,0.0002136929,0.009817939,0.01657526],"study_design_scores_gemma":[0.001406014,0.0001437779,0.004736266,0.0003721478,0.001428335,0.0000108538,0.00007986103,0.9419803,0.02142329,0.0003922308,0.02708246,0.000944495],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8927144,0.02238723,0.0837966,0.0001053343,0.0002648014,0.0002132992,0.000008829499,0.0001093538,0.0004001956],"genre_scores_gemma":[0.9988003,0.0001296107,0.0002345998,0.0001607246,0.0001512413,0.00001026868,0.0001256512,0.00003899912,0.0003486202],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1359834,"threshold_uncertainty_score":0.4677909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00439106913102693,"score_gpt":0.1864073316842777,"score_spread":0.1820162625532507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}