{"id":"W4393986770","doi":"10.1111/acel.14150","title":"Progeria‐based vascular model identifies networks associated with cardiovascular aging and disease","year":2024,"lang":"en","type":"article","venue":"Aging Cell","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; University of Alberta; Stem Cell Network; Agricultural Institute of Canada; Ottawa Hospital","funders":"Canadian Institutes of Health Research; Ottawa Hospital; Canada Research Chairs","keywords":"Progeria; Biology; Lamin; Premature aging; Histone; Vascular smooth muscle; Acetylation; SIRT6; Epigenetics; LMNA; Cell biology; Downregulation and upregulation; Genetics; Sirtuin; Endocrinology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001203097,0.0003945318,0.0001845858,0.0005360063,0.0002435756,0.0003973697,0.0002967383,0.0003654614,0.002139783],"category_scores_gemma":[0.00009988582,0.0001691111,0.0003369463,0.0002652748,0.0002009189,0.000251069,0.0003250563,0.0004886527,0.0004120062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002219816,"about_ca_system_score_gemma":0.0002571893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009872763,"about_ca_topic_score_gemma":0.001199839,"domain_scores_codex":[0.9999297,0.00001154452,0.000003346874,0.00002878624,0.00001255209,0.00001413298],"domain_scores_gemma":[0.9999471,0.000004230979,0.00001685136,0.000007795904,0.00000783322,0.00001622208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006131255,0.0001285351,0.01277845,0.000442215,0.0001757826,0.002154829,0.0001570523,0.001850564,0.9433043,0.007835268,0.003330771,0.02722908],"study_design_scores_gemma":[0.0003366692,0.002054273,0.2847392,0.0002644195,0.0008844196,0.01499813,0.0008203707,0.07352615,0.4693587,0.03087345,0.1220208,0.0001233923],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9046966,0.01103377,0.06257707,0.001712547,0.0003522435,0.0001863303,0.005007246,0.001641706,0.01279251],"genre_scores_gemma":[0.9749111,0.003912325,0.01126588,0.0001491776,0.00006155034,0.0001943385,0.002303133,0.00003568044,0.007166802],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002139783,"threshold_uncertainty_score":0.007158279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00439106913102693,"score_gpt":0.1864073316842777,"score_spread":0.1820162625532507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}