{"id":"W4393987847","doi":"10.20944/preprints202404.0325.v1","title":"Targeted Therapy of Multiple Sclerosis: a Case for Antigen-specific Tregs","year":2024,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Multiple sclerosis; Immunology; Medicine; Antigen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00264364,0.0004044027,0.0007886818,0.0004680384,0.0006732682,0.001827848,0.0007900944,0.004319154,0.002403927],"category_scores_gemma":[0.003025904,0.0001989935,0.0007360833,0.0002999316,0.001999406,0.002605065,0.001016296,0.008118497,0.001266032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008549682,"about_ca_system_score_gemma":0.0006949903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002487259,"about_ca_topic_score_gemma":0.0004074729,"domain_scores_codex":[0.9993078,0.0002061357,0.00003941507,0.0001221258,0.0002130864,0.0001114279],"domain_scores_gemma":[0.9990643,0.000590205,0.00005600016,0.0001111554,0.0001009687,0.00007738125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0008229926,0.0003839211,0.001003419,0.001872341,0.0001112227,0.01812416,0.0009037108,0.0008431552,0.02547162,0.2409457,0.1257901,0.5837276],"study_design_scores_gemma":[0.0002090276,0.0003108021,0.000425795,0.0008582465,0.00006522652,0.02297044,0.000221461,0.0004229188,0.005433304,0.07039988,0.8986524,0.00003048676],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.02309282,0.6591365,0.02204149,0.22499,0.01449918,0.0002016617,0.0002001736,0.0004130772,0.05542506],"genre_scores_gemma":[0.3076803,0.4610747,0.03382166,0.1390267,0.02345332,0.0007275122,0.0002144955,0.0003581565,0.03364308],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.004319154,"threshold_uncertainty_score":0.0139811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3320082352760025,"score_gpt":0.4042277452757418,"score_spread":0.07221950999973936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}