{"id":"W4393988288","doi":"10.1158/1538-7445.am2024-ct002","title":"Abstract CT002: CTX130 allogeneic CRISPR-Cas9-engineered chimeric antigen receptor (CAR) T cells in patients with advanced clear cell renal cell carcinoma: Long-term follow-up and translational data from the phase 1 COBALT-RCC study","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Chimeric antigen receptor; CRISPR; Renal cell carcinoma; Medicine; Antigen; Cancer research; Immunology; Biology; Oncology; Immunotherapy; Immune system; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006212918,0.0002916469,0.0004162595,0.0001158578,0.000210383,0.0005151216,0.0003030653,0.0003322421,0.001031547],"category_scores_gemma":[0.0003880284,0.0001098548,0.0003115032,0.0002256512,0.0002702869,0.0002974788,0.0001544296,0.0008683322,0.0002900922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005448662,"about_ca_system_score_gemma":0.0005758036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001050769,"about_ca_topic_score_gemma":0.00161424,"domain_scores_codex":[0.9998201,0.00005273245,0.00001134976,0.00004561602,0.00003828593,0.00003204075],"domain_scores_gemma":[0.9996418,0.0000562843,0.00009839502,0.00003738556,0.00003755755,0.0001285822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1635917,0.0174619,0.1950303,0.0008648357,0.00197331,0.001170971,0.0006524705,0.009309161,0.3414209,0.0004065998,0.01428295,0.253835],"study_design_scores_gemma":[0.04840255,0.3871319,0.4689266,0.00008310664,0.001708399,0.002833417,0.0003130841,0.01010054,0.06318399,0.0003437484,0.01690004,0.00007266831],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975592,0.0007158846,0.000312225,0.0001250594,0.00001360583,0.00009764478,0.0004409756,0.00003148048,0.0007039679],"genre_scores_gemma":[0.9979558,0.0001916094,0.0002171184,0.0001171137,0.00001376019,0.00004783268,0.00100247,0.000004878361,0.0004493446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001050769,"threshold_uncertainty_score":0.003953278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07240042123301262,"score_gpt":0.3885031541100254,"score_spread":0.3161027328770128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}