{"id":"W4393988374","doi":"10.1158/1538-7445.am2024-ct256","title":"Abstract CT256: Results from KEYNOTE-B98: A phase 1b/2 study of pembrolizumab plus investigational agents in patients with anti-PD-(L)1-refractory extensive-stage small-cell lung cancer (ES-SCLC)","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Lung Cancer Research Studies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Pembrolizumab; Refractory (planetary science); Medicine; Stage (stratigraphy); Oncology; Cancer; Internal medicine; Investigational Drugs; Phases of clinical research; Lung cancer; Chemotherapy; Clinical trial; Immunotherapy; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002295837,0.002269041,0.002204811,0.000449628,0.0005966224,0.001049459,0.001340449,0.002088331,0.01187738],"category_scores_gemma":[0.001589247,0.0006790112,0.001644992,0.000537282,0.001142629,0.001231614,0.0005339775,0.00436272,0.002476174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001093906,"about_ca_system_score_gemma":0.002340016,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001090571,"about_ca_topic_score_gemma":0.003058751,"domain_scores_codex":[0.9994287,0.0003012606,0.0000457934,0.00008802531,0.00004521451,0.00009093185],"domain_scores_gemma":[0.9988267,0.0002085272,0.000220823,0.0001017614,0.00008648559,0.0005556457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9019904,0.04242253,0.002395008,0.000765905,0.001024016,0.0001934566,0.00009386659,0.0008682106,0.02144832,0.0001269503,0.004360293,0.0243111],"study_design_scores_gemma":[0.7692641,0.220549,0.00544575,0.00004522123,0.00061643,0.0001825592,0.00003151229,0.000318834,0.001844474,0.0001094603,0.001570967,0.00002166632],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.97779,0.002729087,0.0006299145,0.001053261,0.0002420729,0.005963027,0.007228076,0.0001914531,0.004173033],"genre_scores_gemma":[0.9699306,0.002386753,0.002400087,0.001688092,0.0003710798,0.00490194,0.01229277,0.00007120404,0.005957485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01187738,"threshold_uncertainty_score":0.03973383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1242814188177862,"score_gpt":0.4492230098884957,"score_spread":0.3249415910707095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}