{"id":"W4393988374","doi":"10.1158/1538-7445.am2024-ct256","title":"Abstract CT256: Results from KEYNOTE-B98: A phase 1b/2 study of pembrolizumab plus investigational agents in patients with anti-PD-(L)1-refractory extensive-stage small-cell lung cancer (ES-SCLC)","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Lung Cancer Research Studies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Pembrolizumab; Refractory (planetary science); Medicine; Stage (stratigraphy); Oncology; Cancer; Internal medicine; Investigational Drugs; Phases of clinical research; Lung cancer; Chemotherapy; Clinical trial; Immunotherapy; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001166186,0.0004713555,0.0009111388,0.001084613,0.0002381716,0.0001266274,0.0005299433,0.0001753387,0.0005856526],"category_scores_gemma":[0.00068247,0.0003744425,0.0001160007,0.001767507,0.0005367409,0.0003463655,0.0004353601,0.001913797,0.00003014404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003128356,"about_ca_system_score_gemma":0.004770706,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.03550272,"about_ca_topic_score_gemma":0.004339909,"domain_scores_codex":[0.9927597,0.0003699117,0.0009375112,0.001417993,0.003315716,0.001199141],"domain_scores_gemma":[0.9957492,0.0008551419,0.0001996798,0.0009357861,0.00172181,0.0005383786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.07471714,0.01957648,0.7321466,0.00861288,0.004736232,0.004422524,0.04811533,0.003189825,0.0238695,0.00004219468,0.07019971,0.0103716],"study_design_scores_gemma":[0.07858862,0.002997254,0.9006752,0.00434337,0.00023385,0.000001081823,0.00325688,0.00160215,0.004753449,0.0000212785,0.002968275,0.0005586426],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98513,0.006764291,0.000003514,0.0008871221,0.000331575,0.004022672,0.002123678,0.00008113286,0.0006560733],"genre_scores_gemma":[0.9952787,0.001264938,0.00004162791,0.0001265664,0.0004031772,0.001022567,0.0002933265,0.0001277698,0.001441333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1685286,"threshold_uncertainty_score":0.9998708,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1242814188177862,"score_gpt":0.4492230098884957,"score_spread":0.3249415910707095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}