{"id":"W4393988417","doi":"10.1158/1538-7445.am2024-ct104","title":"Abstract CT104: Results from a phase 1 study of the anti-immunoglobulin-like transcript 4 (ILT4) monoclonal antibody MK-4830 plus pembrolizumab in patients with previously treated advanced solid tumors","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Princess Margaret Cancer Centre","funders":"","keywords":"Pembrolizumab; Medicine; Antibody; Monoclonal antibody; Cancer research; Oncology; Virology; Internal medicine; Immunotherapy; Immunology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001614286,0.001275216,0.001439682,0.0003923656,0.0005520599,0.0009957283,0.0008354728,0.00106958,0.005521179],"category_scores_gemma":[0.001229204,0.0004324919,0.001208127,0.0005536906,0.0006741009,0.0006939959,0.0004204802,0.002326406,0.001242198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00170605,"about_ca_system_score_gemma":0.002579153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002818182,"about_ca_topic_score_gemma":0.00598183,"domain_scores_codex":[0.9994017,0.0002997837,0.00004280479,0.00009425703,0.00007180188,0.00008968211],"domain_scores_gemma":[0.9989999,0.0001446737,0.0002329919,0.0000818348,0.0001101664,0.0004305194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6713575,0.05388724,0.04647994,0.001135903,0.003675843,0.0007937558,0.0003158875,0.003401794,0.1021702,0.0002395403,0.01807169,0.09847074],"study_design_scores_gemma":[0.3675782,0.4903047,0.1159651,0.0001109845,0.002369578,0.001120986,0.0001297572,0.001467629,0.01144365,0.0002104465,0.009232813,0.00006611116],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856014,0.002262254,0.0004763782,0.0005359931,0.00007991841,0.002266308,0.005591127,0.0001415532,0.003045198],"genre_scores_gemma":[0.9729748,0.001357518,0.001533213,0.001064694,0.0001484491,0.001919589,0.01761497,0.00005049083,0.003336318],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005521179,"threshold_uncertainty_score":0.01847017,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04156949515434699,"score_gpt":0.394824790099123,"score_spread":0.353255294944776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}