{"id":"W4393988434","doi":"10.1158/1538-7445.am2024-ct131","title":"Abstract CT131: Effect of rivoceranib administered as 200 mg once daily on the pharmacokinetics of CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4 substrates","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Altasciences (Canada)","funders":"","keywords":"CYP2C19; CYP2D6; Pharmacokinetics; CYP1A2; CYP3A4; Pharmacology; CYP2C9; Medicine; Chemistry; Cytochrome P450; Internal medicine; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004702584,0.001023496,0.001503846,0.0003440183,0.0002630363,0.0007285373,0.0005523183,0.00102548,0.006481667],"category_scores_gemma":[0.001122627,0.000372808,0.001067053,0.0003641616,0.0006556947,0.0007736978,0.0001870098,0.002849525,0.001083195],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007784423,"about_ca_system_score_gemma":0.001404707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001830962,"about_ca_topic_score_gemma":0.002181688,"domain_scores_codex":[0.9994738,0.0002035643,0.00003459135,0.0001152003,0.0001027433,0.00007023937],"domain_scores_gemma":[0.999427,0.0001129244,0.0001305191,0.00006215935,0.00005432188,0.0002130661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5847092,0.0379596,0.002651938,0.0005343279,0.00114286,0.0003136264,0.0001085068,0.00191517,0.2941239,0.0002643578,0.004791526,0.071485],"study_design_scores_gemma":[0.1509424,0.7252024,0.02063989,0.00004677179,0.0009850676,0.0008440706,0.00006203102,0.0034574,0.09098762,0.0001496605,0.006577506,0.0001051016],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994786,0.0009532605,0.0005340916,0.0001836593,0.0001444921,0.0005528095,0.001178124,0.000167041,0.001500782],"genre_scores_gemma":[0.9913952,0.0006060822,0.001097586,0.0002468628,0.0001388933,0.0003433675,0.002109193,0.000044874,0.004017959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006481667,"threshold_uncertainty_score":0.02168339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1028146353161443,"score_gpt":0.4939783001597105,"score_spread":0.3911636648435662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}