{"id":"W4393988485","doi":"10.1158/1538-7445.am2024-ct207","title":"Abstract CT207: Association of gene expression profiles and clinical outcomes in patients with locally advanced or recurrent/metastatic cutaneous squamous cell carcinoma treated with pembrolizumab in KEYNOTE-629","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; McGill University","funders":"","keywords":"Pembrolizumab; Medicine; Oncology; Basal cell; Internal medicine; Cancer research; Gene; Cancer; Dermatology; Biology; Immunotherapy; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001820535,0.0001245983,0.0002291997,0.0002056394,0.0001454914,0.0002803657,0.0001464503,0.0002035094,0.001495759],"category_scores_gemma":[0.0004724215,0.0000728128,0.0001920487,0.0004139263,0.0001435054,0.0001713038,0.0001344586,0.0002778269,0.0002377307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002464879,"about_ca_system_score_gemma":0.0001581585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000661329,"about_ca_topic_score_gemma":0.0007828757,"domain_scores_codex":[0.999869,0.00002854108,0.00001320308,0.00004432205,0.00002640525,0.00001848681],"domain_scores_gemma":[0.9997213,0.00004945298,0.0001217724,0.0000199807,0.00002620426,0.00006115137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008875286,0.0001873016,0.9715721,0.0000458826,0.0001225004,0.0003003463,0.00004156977,0.0002334936,0.01288337,0.00003179626,0.0003350625,0.005371297],"study_design_scores_gemma":[0.0001123365,0.001299592,0.9956101,0.000004456133,0.00006635772,0.0006777078,0.00004280093,0.0004757716,0.001318991,0.00002487432,0.0003628446,0.000004169232],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991409,0.0001012184,0.00005371927,0.00001180771,0.000001470221,0.000008355838,0.0004150722,0.00000281112,0.000264712],"genre_scores_gemma":[0.9992576,0.00001921836,0.00003451205,0.00001012116,0.000003321266,0.000007763629,0.0005423175,0.000001181227,0.000123946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001495759,"threshold_uncertainty_score":0.00500375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03856893358315928,"score_gpt":0.378995356346328,"score_spread":0.3404264227631687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}