{"id":"W4393988656","doi":"10.1158/1538-7445.am2024-ct282","title":"Abstract CT282: MK-2870-004: A phase 3 study of MK-2870 (SKB264) versus chemotherapy for previously treated advanced or metastatic nonsquamous non-small-cell lung cancer (NSCLC) with <i>EGFR</i> mutations or other genomic alterations","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"William Osler Health System; University of Toronto","funders":"","keywords":"Medicine; Chemotherapy; non-small cell lung cancer (NSCLC); Phases of clinical research; Internal medicine; Oncology; Lung cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001161726,0.001400411,0.001444462,0.000392669,0.000333091,0.0009046338,0.001077177,0.001223543,0.007441326],"category_scores_gemma":[0.0006936394,0.0004449445,0.001182916,0.0003409242,0.0008673085,0.0006293197,0.0002978091,0.003550936,0.001350775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001009836,"about_ca_system_score_gemma":0.001904899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002019105,"about_ca_topic_score_gemma":0.006037905,"domain_scores_codex":[0.9997596,0.0001155751,0.00001068385,0.00003812621,0.00002874758,0.00004718549],"domain_scores_gemma":[0.9995086,0.0000670231,0.00008909043,0.00002468426,0.00003976255,0.0002707311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8061898,0.05326322,0.003170326,0.001712751,0.001308071,0.0002121027,0.000178691,0.003472216,0.05665716,0.0005094089,0.008569462,0.06475673],"study_design_scores_gemma":[0.7115506,0.2734025,0.006063729,0.00005493215,0.0004527644,0.0001678305,0.00004266403,0.001682324,0.004131466,0.0002373686,0.002186476,0.00002739899],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842716,0.002478722,0.0006383507,0.0006749632,0.000196102,0.004756717,0.002591185,0.0002742156,0.004118152],"genre_scores_gemma":[0.9791362,0.001984146,0.001918868,0.00123483,0.0001617799,0.004404751,0.003973608,0.00006971737,0.00711625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007441326,"threshold_uncertainty_score":0.02489364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07977450229271568,"score_gpt":0.4745303498865178,"score_spread":0.3947558475938021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}