{"id":"W4393988692","doi":"10.1158/1538-7445.am2024-ct114","title":"Abstract CT114: Phase 1 study of the anti-immunoglobulin-like transcript 4 (ILT4) monoclonal antibody MK-4830 plus pembrolizumab in patients with previously untreated advanced head and neck squamous cell carcinoma (HNSCC) or non-small cell lung cancer (NSCLC)","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Ottawa Hospital","funders":"","keywords":"Pembrolizumab; Head and neck squamous-cell carcinoma; Medicine; Antibody; Monoclonal antibody; Head and neck; Cancer research; Internal medicine; Oncology; Head and neck cancer; Cancer; Immunotherapy; Immunology; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00107491,0.001694462,0.001573642,0.0004856599,0.0005150504,0.0008872062,0.00113869,0.001162568,0.004938175],"category_scores_gemma":[0.0007129731,0.0006301945,0.001199577,0.0004478203,0.0007312333,0.0006648622,0.0004208427,0.00314079,0.001123654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001591009,"about_ca_system_score_gemma":0.002594046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002706524,"about_ca_topic_score_gemma":0.008417979,"domain_scores_codex":[0.9996758,0.0001414553,0.00001671883,0.00006369085,0.0000375989,0.00006476724],"domain_scores_gemma":[0.9994885,0.00005837173,0.0001076628,0.00004053191,0.00004326334,0.0002615932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7005638,0.08008926,0.01774316,0.001165885,0.001783646,0.0004399991,0.0002897095,0.003569891,0.1120708,0.0002485862,0.006513391,0.07552192],"study_design_scores_gemma":[0.4830754,0.4759322,0.02809271,0.00004379774,0.0007406931,0.0003467385,0.00006200752,0.001015682,0.007406943,0.0001027185,0.003147674,0.00003356264],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894809,0.001263637,0.0004213765,0.0003110252,0.00009621935,0.00391139,0.002430378,0.0001223529,0.001962629],"genre_scores_gemma":[0.9853302,0.00116499,0.001410517,0.0006077573,0.000117707,0.00316599,0.004714725,0.0000318832,0.003456234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004938175,"threshold_uncertainty_score":0.0165199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03041345447476762,"score_gpt":0.3604095163433503,"score_spread":0.3299960618685827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}